Development of a nucleoside-modified mRNA vaccine against clade 2.3.4.4b H5 highly pathogenic avian influenza virus

• Published in: Nature communications Vol. 15; no. 1; pp. 4350 - 12
• Main Authors: Furey, Colleen, Scher, Gabrielle, Ye, Naiqing, Kercher, Lisa, DeBeauchamp, Jennifer, Crumpton, Jeri Carol, Jeevan, Trushar, Patton, Christopher, Franks, John, Rubrum, Adam, Alameh, Mohamad-Gabriel, Fan, Steven H. Y., Phan, Anthony T., Hunter, Christopher A., Webby, Richard J., Weissman, Drew, Hensley, Scott E.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.05.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/106; 49; 631/1647/334/1874/345; 631/250/590/2293; 631/326/596/1578; 64; 64/60; 82/1; Animal models; Animals; Antibodies; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; Avian flu; Birds; Birds - virology; Female; Females; Ferrets; Glycoproteins; Hemagglutinin Glycoproteins, Influenza Virus - genetics; Hemagglutinin Glycoproteins, Influenza Virus - immunology; Hemagglutinins; Humanities and Social Sciences; Humans; Immunogenicity; Influenza; Influenza A Virus, H1N1 Subtype - genetics; Influenza A Virus, H1N1 Subtype - immunology; Influenza A Virus, H5N1 Subtype - genetics; Influenza A Virus, H5N1 Subtype - immunology; Influenza in Birds - immunology; Influenza in Birds - prevention & control; Influenza in Birds - virology; Influenza Vaccines - administration & dosage; Influenza Vaccines - immunology; Lipids; Lipids - chemistry; Liposomes; Lymphocytes; Lymphocytes T; Male; Mice; Mice, Inbred BALB C; Morbidity; mRNA; mRNA Vaccines - immunology; multidisciplinary; Mustela; Nanoparticles; Nanoparticles - chemistry; Orthomyxoviridae; Orthomyxoviridae Infections - immunology; Orthomyxoviridae Infections - prevention & control; Orthomyxoviridae Infections - virology; Pandemics; RNA, Messenger - genetics; RNA, Messenger - immunology; RNA, Messenger - metabolism; Science; Science (multidisciplinary); Vaccines; Viruses

mRNA lipid nanoparticle (LNP) vaccines would be useful during an influenza virus pandemic since they can be produced rapidly and do not require the generation of egg-adapted vaccine seed stocks. Highly pathogenic avian influenza viruses from H5 clade 2.3.4.4b are circulating at unprecedently high le...