Serum Level of Tumor-Overexpressed AGR2 Is Significantly Associated with Unfavorable Prognosis of Canine Malignant Mammary Tumors

• Published in: Animals (Basel) Vol. 11; no. 10; p. 2923
• Main Authors: Yuan, Stephen Hsien-Chi, Chang, Shih-Chieh, Huang, Yenlin, Liu, Hao-Ping
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 09.10.2021; MDPI
• Subjects: AGR2; biomarkers; blood serum; Breast cancer; canine; Disease; Dogs; enzyme-linked immunosorbent assay; females; Gene expression; immunoblotting; immunohistochemistry; Life sciences; mammary tumors; Mastectomy; Medical prognosis; metastasis; Monoclonal antibodies; Pathogenesis; Pets; prognosis; protein disulfide-isomerase; Proteins; secretion; serum; tumor metastasis; Tumors; Vascular endothelial growth factor; United States > US; Germany; Taiwan

Canine malignant mammary tumors (MMTs) are prevalent malignancy in intact female dogs with a high incidence of metastasis and recurrence. A current lack of easily accessible tumor biomarkers hinders a timely assessment of the disease outcome. We previously identified anterior gradient protein 2 (AGR...