Preneoplastic cells switch to Warburg metabolism from their inception exposing multiple vulnerabilities for targeted elimination

• Published in: Oncogenesis (New York, NY) Vol. 13; no. 1; pp. 7 - 9
• Main Authors: Myllymäki, Henna, Kelly, Lisa, Elliot, Abigail M., Carter, Roderick N., Johansson, Jeanette Astorga, Chang, Kai Yee, Cholewa-Waclaw, Justyna, Morton, Nicholas M., Feng, Yi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.01.2024; Nature Publishing Group
• Subjects: 13/2; 13/51; 14/19; 631/67/2195; 631/67/2327; 64; 64/116; Apoptosis; Brief Communication; Cell activation; Cell Biology; Electron transport chain; Energy metabolism; Glycolysis; Human Genetics; Internal Medicine; Medicine; Medicine & Public Health; Metabolism; Metformin; Oncology; Oxidative phosphorylation; Phosphorylation; Somatic cells; Tumors

Otto Warburg described tumour cells as displaying enhanced aerobic glycolysis whilst maintaining defective oxidative phosphorylation (OXPHOS) for energy production almost 100 years ago [ 1 , 2 ]. Since then, the ‘Warburg effect’ has been widely accepted as a key feature of rapidly proliferating canc...