Molecular basis of ligand recognition by OASS from E. histolytica: Insights from structural and molecular dynamics simulation studies - Raj, Isha; Mazumder, Mohit; Gourinath, Samudrala (Biochimica et biophysica acta, 2013)
Keywords: Active site cleft; active sites; biochemical pathways; Conformational change; Crystallography, X-Ray; cysteine; Cysteine biosynthetic pathway; Cysteine Synthase - chemistry; Cysteine Synthase - metabolism; energy; Entamoeba histolytica; Entamoeba histolytica - enzymology; Inhibition; isoleucine; Ligand binding; Ligands; lysine; methionine; Models, Molecular; molecular dynamics; Molecular Dynamics Simulation; nitrogen; O-acetyl serine sulfhydrylase; pyridoxal phosphate; schiff bases; X-ray diffraction; Ligand binding; Cysteine biosynthetic pathway; Inhibition; Conformational change; O-acetyl serine sulfhydrylase; Active site cleft