Ultrasound-activated piezo-hot carriers trigger tandem catalysis coordinating cuproptosis-like bacterial death against implant infections

• Published in: Nature communications Vol. 15; no. 1; pp. 1643 - 17
• Main Authors: Huang, Yanli, Wan, Xufeng, Su, Qiang, Zhao, Chunlin, Cao, Jian, Yue, Yan, Li, Shuoyuan, Chen, Xiaoting, Yin, Jie, Deng, Yi, Zhang, Xianzeng, Wu, Tianmin, Zhou, Zongke, Wang, Duan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.02.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 119/118; 13/51; 14/63; 140/133; 147/135; 147/143; 38/91; 631/61/54/994; 639/301/54; 639/301/54/990; 639/301/54/993; 639/301/923; 64/86; Angiogenesis; Antiinfectives and antibacterials; Bacteria; Barium; Barium titanates; Biofilms; Catalysis; Chemical reactions; Copper; DNA damage; DNA structure; Humanities and Social Sciences; Hydroxyl radicals; Infections; Membrane structure; Membrane structures; Metabolomics; multidisciplinary; Osteogenesis; Oxygen; Piezoelectricity; Polyetherketoneketones; Reactive oxygen species; Scaffolds; Science; Science (multidisciplinary); Transcriptomics; Tricarboxylic acid cycle; Ultrasonic imaging; Ultrasound

Implant-associated infections due to the formation of bacterial biofilms pose a serious threat in medical healthcare, which needs effective therapeutic methods. Here, we propose a multifunctional nanoreactor by spatiotemporal ultrasound-driven tandem catalysis to amplify the efficacy of sonodynamic...