Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression - Straub, R E; Lipska, B K; Egan, M F; Goldberg, T E; Callicott, J H; Mayhew, M B; Vakkalanka, R K; Kolachana, B S; Kleinman, J E; Weinberger, D R (Molecular psychiatry, 2007)
Keywords: Acids; Adolescent; Adult; Adult and adolescent clinical studies; Alleles; Allelomorphism; Behavioral Sciences; Biological and medical sciences; Biological Psychology; Brain mapping; Catechol; Catechol O-methyltransferase; Catechol O-Methyltransferase - genetics; Cerebral Cortex - blood supply; Cerebral Cortex - physiopathology; Cognition; Cognition & reasoning; Development and progression; Dopamine receptors; Enzymes; Epistasis; Etiology; Family Health; Female; Functional magnetic resonance imaging; GABA; Gene expression; Gene Expression - physiology; Gene Frequency; Gene polymorphism; Genetic aspects; Genetic epistasis; Genetic Predisposition to Disease; Genomes; Glutamate decarboxylase; Glutamate Decarboxylase - genetics; Glutamic acid; Humans; Hypotheses; Image Processing, Computer-Assisted - methods; Linkage Disequilibrium; Magnetic Resonance Imaging - methods; Male; Medical sciences; Medicine; Medicine & Public Health; Memory; Mental disorders; Mental health; Mental task performance; Methyltransferase; Middle Aged; Neuroimaging; Neuropsychological Tests; Neurosciences; original-article; Oxygen - blood; Pathophysiology; Pharmacotherapy; Phenotypes; Physiological aspects; Polymorphism, Single Nucleotide; Prefrontal cortex; Proteins; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Psychosis; Schizophrenia; Schizophrenia - genetics; Schizophrenia - pathology; Schizophrenia - physiopathology; Sex Factors; Short term memory; Single-nucleotide polymorphism; γ-Aminobutyric acid; United States--US; epistasis; GAD; schizophrenia; Enzyme; Transferases; GAD1; Schizophrenia; Catechol O-methyltransferase; Gene expression; COMT; GAD67; Genetic determinism; Psychosis; Methyltransferases; Genetics