Salinomycin induces apoptosis and senescence in breast cancer: Upregulation of p21, downregulation of survivin and histone H3 and H4 hyperacetylation - Al Dhaheri, Yusra; Attoub, Samir; Arafat, Kholoud; AbuQamar, Synan; Eid, Ali; Al Faresi, Nesreen; Iratni, Rabah (Biochimica et biophysica acta, 2013)
Keywords: Acetylation; Anti-Bacterial Agents - pharmacology; Apoptosis; Apoptosis - drug effects; beta-galactosidase; breast neoplasms; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; caspases; cell cycle; Cell Line, Tumor; Cell Proliferation - drug effects; cell viability; Cellular Senescence - drug effects; Cyclin-Dependent Kinase Inhibitor p21 - genetics; Cyclin-Dependent Kinase Inhibitor p21 - physiology; Cytoskeletal Proteins - metabolism; DNA damage; drug therapy; Female; flow cytometry; fluorescent antibody technique; G2 Phase - drug effects; Glycosides - pharmacology; Histone hyperacetylation; histones; Histones - metabolism; Humans; Inhibitor of Apoptosis Proteins - antagonists & inhibitors; Inhibitor of Apoptosis Proteins - physiology; mechanism of action; neoplasm cells; p21; pro-apoptotic proteins; propidium; protein synthesis; Pyrans - pharmacology; Salinomycin; Senescence-associated beta galactosidase (SA-β-Gal); Survivin; Triterpenes - pharmacology; Western blotting; DMSO; Histone hyperacetylation; DNA damage; Senescence-associated beta galactosidase (SA-β-Gal); TBST; PARP; FACS; Fr; RIPA; p21; DMEM; SA-β-Gal; SDS-PAGE; X-gal; Salinomycin; 4-HT; Apoptosis