Ferroptosis, Necroptosis, and Pyroptosis in Gastrointestinal Cancers: The Chief Culprits of Tumor Progression and Drug Resistance

• Published in: Advanced science Vol. 10; no. 26; pp. e2300824 - n/a
• Main Authors: Zhu, Xudong, Li, Shenglong
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.09.2023; John Wiley and Sons Inc; Wiley
• Subjects: Apoptosis; Autophagy; Colorectal cancer; Drug Resistance; Ferroptosis; Gastric cancer; gastrointestinal cancers; Gastrointestinal Neoplasms - drug therapy; Humans; Kinases; Lipids; Metabolism; Necroptosis; Oxidative stress; Phosphorylation; Proteins; Pyroptosis; Review; Reviews; targeted therapy; gastrointestinal cancers; pyroptosis; targeted therapy; ferroptosis; drug resistance; necroptosis

In recent years, the incidence of gastrointestinal cancers is increasing, particularly in the younger population. Effective treatment is crucial for improving patients’ survival outcomes. Programmed cell death, regulated by various genes, plays a fundamental role in the growth and development of org...