TET2-mediated tumor cGAS triggers endothelial STING activation to regulate vasculature remodeling and anti-tumor immunity in liver cancer

• Published in: Nature communications Vol. 15; no. 1; pp. 6 - 21
• Main Authors: Lv, Hongwei, Zong, Qianni, Chen, Cian, Lv, Guishuai, Xiang, Wei, Xing, Fuxue, Jiang, Guoqing, Yan, Bing, Sun, Xiaoyan, Ma, Yue, Wang, Liang, Wu, Zixin, Cui, Xiuliang, Wang, Hongyang, Yang, Wen
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.01.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 14; 38; 42; 42/89; 59; 59/5; 631/67/1059/2325; 631/67/1504/1610/4029; 631/67/2328; 64; 64/60; 96; Anticancer properties; Antitumor agents; Ascorbic acid; Crosstalk; Effectiveness; Endothelial cells; Humanities and Social Sciences; Immune response; Immune system; Immunity; Immunotherapy; In vivo methods and tests; Interleukin 2; Leukocyte migration; Liver cancer; Lymphocytes; Males; Microenvironments; multidisciplinary; PD-L1 protein; Science; Science (multidisciplinary); Tumors

Induction of tumor vascular normalization is a crucial measure to enhance immunotherapy efficacy. cGAS-STING pathway is vital for anti-tumor immunity, but its role in tumor vasculature is unclear. Herein, using preclinical liver cancer models in Cgas / Sting -deficient male mice, we report that the...