Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans

• Published in: Nature microbiology Vol. 5; no. 12; pp. 1598 - 1607
• Main Authors: Seow, Jeffrey, Graham, Carl, Merrick, Blair, Acors, Sam, Pickering, Suzanne, Steel, Kathryn J. A., Hemmings, Oliver, O’Byrne, Aoife, Kouphou, Neophytos, Galao, Rui Pedro, Betancor, Gilberto, Wilson, Harry D., Signell, Adrian W., Winstone, Helena, Kerridge, Claire, Huettner, Isabella, Jimenez-Guardeño, Jose M., Lista, Maria Jose, Temperton, Nigel, Snell, Luke B., Bisnauthsing, Karen, Moore, Amelia, Green, Adrian, Martinez, Lauren, Stokes, Brielle, Honey, Johanna, Izquierdo-Barras, Alba, Arbane, Gill, Patel, Amita, Tan, Mark Kia Ik, O’Connell, Lorcan, O’Hara, Geraldine, MacMahon, Eithne, Douthwaite, Sam, Nebbia, Gaia, Batra, Rahul, Martinez-Nunez, Rocio, Shankar-Hari, Manu, Edgeworth, Jonathan D., Neil, Stuart J. D., Malim, Michael H., Doores, Katie J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2020; Nature Publishing Group
• Subjects: 38/109; 631/250/2152; 631/250/254; 631/250/255; 631/326/596; 82; 82/1; 82/80; 82/83; Adult; Aged; Aged, 80 and over; Antibodies; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antibodies, Viral - blood; Antibodies, Viral - immunology; Antibody response; Biomedical and Life Sciences; COVID-19; COVID-19 - blood; COVID-19 - immunology; COVID-19 - pathology; Female; Humans; Immunoglobulin A; Immunoglobulin G; Infections; Infectious Diseases; Kinetics; Life Sciences; Longitudinal Studies; Male; Medical Microbiology; Medical personnel; Microbiology; Middle Aged; Parasitology; SARS-CoV-2 - immunology; Seroconversion; Severe acute respiratory syndrome coronavirus 2; Severity of Illness Index; Virology; Young Adult

Antibody responses to SARS-CoV-2 can be detected in most infected individuals 10–15 d after the onset of COVID-19 symptoms. However, due to the recent emergence of SARS-CoV-2 in the human population, it is not known how long antibody responses will be maintained or whether they will provide protecti...