The smooth muscle cell membrane during atherogenesis: A potential target for amlodipine in atheroprotection

• Published in: The American heart journal Vol. 141; no. 2; pp. S1 - S11
• Main Authors: Tulenko, T.N., Sumner, A.E., Chen, M., Huang, Y., Laury-Kleintop, L., Ferdinand, F.D.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Mosby, Inc 01.02.2001; Elsevier
• Subjects: Amlodipine - therapeutic use; Animals; Arteriosclerosis - metabolism; Arteriosclerosis - pathology; Arteriosclerosis - prevention & control; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Calcium - metabolism; Calcium Channel Blockers - therapeutic use; Cardiology. Vascular system; Cell Membrane - drug effects; Cell Membrane - metabolism; Cell Membrane - ultrastructure; Cell Membrane Permeability - drug effects; Cholesterol, LDL - metabolism; Disease Progression; Humans; Medical sciences; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - pathology; Risk Factors; Cell proliferation; Pharmacologic test; Vasodilator agent; Calcium antagonist; Rabbit; Cardiovascular disease; Smooth muscle; Lagomorpha; Vascular disease; Vertebrata; Mammalia; Animal; Atherosclerosis; Plasma membrane; Amlodipine; Dihydropyridine derivatives

Background Atherosclerotic disease has been present in the human population apparently from the beginning of time. However, it has only been in the 20th century that improvements in the control of infectious diseases have allowed the average life span to increase to the point where atherosclerosis h...