Visualization of cristae and mtDNA interactions via STED nanoscopy using a low saturation power probe

• Published in: Light, science & applications Vol. 13; no. 1; pp. 116 - 16
• Main Authors: Ren, Wei, Ge, Xichuan, Li, Meiqi, Sun, Jing, Li, Shiyi, Gao, Shu, Shan, Chunyan, Gao, Baoxiang, Xi, Peng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.05.2024; Springer Nature B.V; Nature Publishing Group
• Subjects: 639/624/1107/328/2238; 639/624/1111/55; Apoptosis; Cristae; DNA probes; Ferroptosis; Lasers; Lipid membranes; Microscopy; Microwaves; Mitochondria; Mitochondrial DNA; Optical and Electronic Materials; Optical Devices; Optics; Organelles; Photonics; Physics; Physics and Astronomy; RF and Optical Engineering; Spatial discrimination

Mitochondria are crucial organelles closely associated with cellular metabolism and function. Mitochondrial DNA (mtDNA) encodes a variety of transcripts and proteins essential for cellular function. However, the interaction between the inner membrane (IM) and mtDNA remains elusive due to the limitat...