Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant HepG2 cells

• Published in: Journal of ethnopharmacology Vol. 259; no. NA; p. 113015
• Main Authors: Li, Pan, Ding, Liqin, Cao, Shijie, Feng, Xinchi, Zhang, Qiang, Chen, Yuwei, Zhang, Nan, Qiu, Feng
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 15.09.2020
• Subjects: active ingredients; Ayurvedic medicine; Biotransformation; cell culture; China; culture media; Curcuma longa; Curcumin; Curcumin - metabolism; Curcumin - pharmacology; diabetes; Drug Stability; Extracellular Signal-Regulated MAP Kinases - metabolism; glucose; Glucose - metabolism; Glycogen Synthase Kinase 3 beta - metabolism; Hep G2 Cells; Hepatocytes - drug effects; Hepatocytes - metabolism; HepG2 cells; human cell lines; Humans; insulin; Insulin - pharmacology; Insulin Resistance; Insulin sensitivity; JNK Mitogen-Activated Protein Kinases - metabolism; metabolism; Metabolites; mitogen-activated protein kinase; Network pharmacology; Oriental traditional medicine; pharmacology; Phosphatidylinositol 3-Kinase - metabolism; Phosphorylation; Proto-Oncogene Proteins c-akt - metabolism; prototypes; Signal Transduction; turmeric; Western blotting; China; Dihydrocurcumin (Pubchem CID; Tetrahydrocurcumin (Pubchem CID; Metabolites; Insulin sensitivity; Curcumin (Pubchem CID; Vanillin (Pubchem CID; Curcumin; Network pharmacology; HepG2 cells; hexahydroxycurcumin (Pubchem CID; Octahydrocurcumin (Pubchem CID; vanillin acetal (Pubchem CID

Curcumin (CUR) is the active ingredient of Traditional Chinese Medicine turmeric (Curcuma longa L.), which has been used for treatment of diabetes in Ayurveda and China. CUR exerts potent anti-insulin-resistant effects in various cell lines. However, previous studies indicated CUR was metabolized ex...