Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant HepG2 cells - Li, Pan; Ding, Liqin; Cao, Shijie; Feng, Xinchi; Zhang, Qiang; Chen, Yuwei; Zhang, Nan; Qiu, Feng (Journal of ethnopharmacology, 2020)
Keywords: active ingredients; Ayurvedic medicine; Biotransformation; cell culture; China; culture media; Curcuma longa; Curcumin; Curcumin - metabolism; Curcumin - pharmacology; diabetes; Drug Stability; Extracellular Signal-Regulated MAP Kinases - metabolism; glucose; Glucose - metabolism; Glycogen Synthase Kinase 3 beta - metabolism; Hep G2 Cells; Hepatocytes - drug effects; Hepatocytes - metabolism; HepG2 cells; human cell lines; Humans; insulin; Insulin - pharmacology; Insulin Resistance; Insulin sensitivity; JNK Mitogen-Activated Protein Kinases - metabolism; metabolism; Metabolites; mitogen-activated protein kinase; Network pharmacology; Oriental traditional medicine; pharmacology; Phosphatidylinositol 3-Kinase - metabolism; Phosphorylation; Proto-Oncogene Proteins c-akt - metabolism; prototypes; Signal Transduction; turmeric; Western blotting; China; Dihydrocurcumin (Pubchem CID; Tetrahydrocurcumin (Pubchem CID; Metabolites; Insulin sensitivity; Curcumin (Pubchem CID; Vanillin (Pubchem CID; Curcumin; Network pharmacology; HepG2 cells; hexahydroxycurcumin (Pubchem CID; Octahydrocurcumin (Pubchem CID; vanillin acetal (Pubchem CID