The impact of GLP-1 receptor agonist liraglutide on blood pressure profile, hydration, natriuresis in diabetic patients with severely impaired kidney function

• Published in: Scientific reports Vol. 14; no. 1; pp. 5002 - 10
• Main Authors: Wajdlich, Małgorzata, Nowicki, Michał
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.02.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 692/4022/1585/104; 692/699/75/243; Agonists; Aldosterone; Antidiabetics; Atrial natriuretic peptide; Blood pressure; Diabetes; Diabetes mellitus; Diabetic kidney disease; Epidermal growth factor receptors; GLP-1 receptor agonists; Humanities and Social Sciences; Hydration; Kidney diseases; Kidneys; Liraglutide; multidisciplinary; Natriuresis; Placebos; Plasma; Renin; Renin–angiotensin–aldosterone system; Science; Science (multidisciplinary); Thorax; Blood pressure; Natriuresis; Renin–angiotensin–aldosterone system; Liraglutide; Diabetic kidney disease

Chronic treatment with GLP-1R agonists may moderately lower blood pressure due to increased natriuresis and RAAS inhibition. Short-term effect of these drugs on blood pressure may be opposite and its mechanism remains unclear. We investigated the effect of a single dose of liraglutide on diurnal blo...