Anti-inflammatory effects of luteolin: A review of in vitro, in vivo, and in silico studies

• Published in: Journal of ethnopharmacology Vol. 225; no. NA; pp. 342 - 358
• Main Authors: Aziz, Nur, Kim, Mi-Yeon, Cho, Jae Youl
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 28.10.2018
• Subjects: anti-inflammatory activity; clinical trials; Flavonoid; Inflammatory diseases; Inflammatory signaling; Luteolin; medicinal plants; mitogen-activated protein kinase; signal transduction; therapeutics; traditional medicine; transactivators; transcription (genetics); transcription factor NF-kappa B; JNK; ICAM-1; HMGB1; Luteolin (PubChem CID: 5280445); AP-1; CXCL2; MyD88; NF-κB; IFN-β; TBK1; PI3K; PRV; iNOS; Syk; PKC; MAPK; IL-1β; IP-10; SIRT1; MMP; ERK1/2; BMMCs; MIP; ROS; IRF; TRIF; HUVECs; HDAC; NO; MCP-1; COX-2; Src; HO-1; Flavonoid; LPS; Inflammatory diseases; NFAT; Luteolin-7-O-glucoside (PubChem CID: 5280637); IκB; GFP; LDH; CREB; CCL2; TLR; Luteolin; Inflammatory signaling; GSH; Luteolin-6-C-glucoside (PubChem CID: 49852298); PGE2; HSP90; NK cells; PMA; STAT3; IKK; SOD; AKT; SOCS; Luteolin-8-C-glucoside (PubChem CID: 5281675); VCAM-1; TNF-α; JAK; LTC4; HAT; ATP; TIMP; Luteolin-5-O-glucoside (PubChem CID: 44258061)

Luteolin (3′, 4′, 5,7-tetrahydroxyflavone) has been identified as commonly present in plants. Plants with a high luteolin content have been used ethnopharmacologically to treat inflammation-related symptoms. Both isolated luteolin and extracts from luteolin-rich plants have been studied using variou...