Formation and stability of interpenetrating polymer network hydrogels consisting of fibrin and hyaluronic acid for tissue engineering

• Published in: Acta biomaterialia Vol. 9; no. 2; pp. 5143 - 5152
• Main Authors: Lee, Fan, Kurisawa, Motoichi
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2013
• Subjects: Animals; Cattle; Cell Movement; Cell Movement - drug effects; cell proliferation; Cell Proliferation - drug effects; Cell Survival; Cell Survival - drug effects; chemical synthesis; chemistry; crosslinking; cytology; drug effects; Fibrin; Fibrin - pharmacology; fibrinogen; Fibrinolysin; Fibrinolysin - pharmacology; Fibroblasts; Fibroblasts - cytology; Fibroblasts - drug effects; gels; Human Umbilical Vein Endothelial Cells; Human Umbilical Vein Endothelial Cells - cytology; Human Umbilical Vein Endothelial Cells - drug effects; Humans; Hyaluronic acid; Hyaluronic Acid - pharmacology; hydrocolloids; Hydrogel; Hydrogels; Hydrogels - chemical synthesis; hydrogen peroxide; Interpenetrating polymer network; mechanical properties; methods; Neovascularization, Physiologic; Neovascularization, Physiologic - drug effects; peroxidase; pharmacology; plasmin; polymerization; polymers; Polymers - chemical synthesis; Rheology; Rheology - drug effects; storage modulus; thrombin; tissue engineering; Tissue Engineering - methods; tissue scaffolds; tyramine; Tyramine - chemistry; Vascularization; Fibrin; Hydrogel; Hyaluronic acid; Interpenetrating polymer network; Vascularization

Fibrin gel is widely used as a tissue engineering scaffold. However, it has poor mechanical properties, which often result in rapid contraction and degradation of the scaffold. An interpenetrating polymer network (IPN) hydrogel composed of fibrin and hyaluronic acid–tyramine (HA–Tyr) was developed t...