Involvement of the GABAergic system in the anxiolytic-like effect of the flavonoid ellagic acid in mice

• Published in: European journal of pharmacology Vol. 710; no. 1-3; pp. 49 - 58
• Main Authors: Girish, Chandrashekaran, Raj, Vishnu, Arya, Jayasree, Balakrishnan, Sadasivam
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.06.2013
• Subjects: acid treatment; administration & dosage; Animals; antagonists; Anti-Anxiety Agents; Anti-Anxiety Agents - administration & dosage; Antianxiety; Anxiety; Anxiety - drug therapy; Anxiety - physiopathology; diazepam; Dose-Response Relationship, Drug; drug effects; drug therapy; Ellagic acid; Ellagic Acid - administration & dosage; Flavonoid; flavonoids; Flumazenil; Flumazenil - pharmacology; fruits; GABA; GABA-A Receptor Antagonists; GABA-A Receptor Antagonists - pharmacology; Male; Mice; Motor Activity; Motor Activity - drug effects; pharmacology; physiology; physiopathology; Picrotoxin; Picrotoxin - pharmacology; Receptors, GABA-A; Receptors, GABA-A - physiology; Serotonin; sodium; GABA; Antianxiety; Mice; Serotonin; Flavonoid; Ellagic acid

Anxiolytic-like effects of dietary flavonoids are relatively well known. Ellagic acid is a naturally occurring flavonoid compound which is abundant in many plants and fruits. The present study was designed to investigate the antianxiety-like effect of ellagic acid in mice using an elevated plus-maze...