Antihypertensive effect of Valyl-Tyrosine, a short chain peptide derived from sardine muscle hydrolyzate, on mild hypertensive subjects

• Published in: Journal of human hypertension Vol. 14; no. 8; pp. 519 - 523
• Main Authors: Kawasaki, T, Seki, E, Osajima, K, Yoshida, M, Asada, K, Matsui, T, Osajima, Y
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing 01.08.2000; Nature Publishing Group
• Subjects: Adult; Aldosterone; Aldosterone - blood; Angiotensin; Angiotensin I - blood; Angiotensin II; Angiotensin II - blood; Animals; Antihypertensive agents; Antihypertensive Agents - therapeutic use; Antihypertensives; Biological and medical sciences; Blood pressure; Cardiovascular system; Dipeptides - therapeutic use; Double-Blind Method; Double-blind studies; Female; Fishes - metabolism; Humans; Hydrolysis; Hypertension; Hypertension - drug therapy; Hypertension - physiopathology; Male; Medical sciences; Middle Aged; Muscles - metabolism; Pharmacology. Drug treatments; Placebos; Reference Values; Tyrosine; Hypertension; Sardine; Tyrosine; Rat; Treatment efficiency; Rodentia; Cardiovascular disease; Genetic disease; Vertebrata; Chemotherapy; Mammalia; Treatment; Hydrolysate; Animal; Muscle

The present study was conducted to determine whether Valyl-Tyrosine (VY) has an antihypertensive effect on high-normal blood pressure and mild essential hypertension, as well as spontaneous hypertensive rats (SHR). A randomised double-blind placebo-controlled study was carried out on 29 volunteers....