Prolonged response without prolonged chemotherapy: a lesson from PCV chemotherapy in low-grade gliomas

• Published in: Neuro-oncology (Charlottesville, Va.) Vol. 12; no. 10; pp. 1078 - 1082
• Main Authors: Peyre, Matthieu, Cartalat-Carel, Stéphanie, Meyronet, David, Ricard, Damien, Jouvet, Anne, Pallud, Johan, Mokhtari, Karima, Guyotat, Jacques, Jouanneau, Emmanuel, Sunyach, Marie-Pierre, Frappaz, Didier, Honnorat, Jérôme, Ducray, François
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.10.2010
• Subjects: Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Brain Neoplasms - drug therapy; Brain Neoplasms - pathology; Clinical Investigations; Female; Glioma - drug therapy; Glioma - pathology; Humans; Lomustine - administration & dosage; Lomustine - therapeutic use; Magnetic Resonance Imaging; Male; Procarbazine - administration & dosage; Procarbazine - therapeutic use; Retrospective Studies; Vincristine - administration & dosage; Vincristine - therapeutic use; growth kinetics; low-grade glioma; PCV chemotherapy

Previous studies with temozolomide suggest that a prolonged duration of chemotherapy is important for treating low-grade gliomas (LGGs). PCV (procarbazine, CCNU, vincristine) chemotherapy has demonstrated efficacy in treating LGGs, but this therapy cannot be used for a prolonged period because of th...