Circular RNA OMA1 regulates the progression of breast cancer via modulation of the miR‑1276/SIRT4 axis

• Published in: Molecular medicine reports Vol. 24; no. 4
• Main Authors: Xu, Lingli, Xu, Ke, Xiang, Lijun, Yan, Jiamei
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.10.2021; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Adult; Aged; Apoptosis; Biomarkers, Tumor - genetics; Breast cancer; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer therapies; Carcinogenesis - genetics; Cell Line, Tumor; Cell Movement; Cell Survival; Circular RNA; Development and progression; DNA microarrays; Gene expression; Gene Expression Regulation, Neoplastic; Genetic aspects; Health aspects; HEK293 Cells; Humans; Lymph nodes; Metalloendopeptidases - genetics; Metalloendopeptidases - metabolism; Metastases; Metastasis; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; miRNA; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; Physiological aspects; Plasmids; Prognosis; Reverse transcription; RNA; RNA polymerase; RNA, Circular; Sirtuins - genetics; Sirtuins - metabolism; Tumorigenesis; Young Adult; China; microRNA‑1276; breast cancer; circular RNA OMA1; sirtuin 4

Mounting evidence has indicated that circular RNAs (circRNAs) serve essential roles in the tumorigenesis and development of various types of cancer. However, the biological functions and the underlying mechanisms of circRNAs in breast cancer (BC) remain largely elusive. In the present study, the exp...