Circular RNA OMA1 regulates the progression of breast cancer via modulation of the miR‑1276/SIRT4 axis
Mounting evidence has indicated that circular RNAs (circRNAs) serve essential roles in the tumorigenesis and development of various types of cancer. However, the biological functions and the underlying mechanisms of circRNAs in breast cancer (BC) remain largely elusive. In the present study, the exp...
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Published in | Molecular medicine reports Vol. 24; no. 4 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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01.10.2021
Spandidos Publications UK Ltd D.A. Spandidos |
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Abstract | Mounting evidence has indicated that circular RNAs (circRNAs) serve essential roles in the tumorigenesis and development of various types of cancer. However, the biological functions and the underlying mechanisms of circRNAs in breast cancer (BC) remain largely elusive. In the present study, the expression pattern of circRNAs in three pairs of BC tissues and adjacent normal tissues was determined using a circRNA microarray. The expression and prognostic value of circOMA1 were evaluated by reverse transcription‑quantitative PCR in 64 pairs of BC tissues and adjacent normal tissues. Survival curves were generated by the Kaplan‑Meier method, and statistical significance was estimated using the log‑rank test. A series of
functional experiments were then performed to investigate the role of circOMA1 in the tumorigenesis of BC. The results revealed that the expression levels of circOMA1 were upregulated in BC tissues, and its expression was markedly associated with tumor size and lymph node metastasis. Receiver operating characteristic analysis demonstrated that the expression of circOMA1 could be used to discriminate between BC tissues and adjacent normal tissues. Functionally, overexpression of circOMA1 promoted the viability, migration and invasion of BC cells, whereas circOMA1 knockdown had the opposite effect. Mechanistic investigations showed that circOMA1 promoted the progression of BC by sponging microRNA (miR)‑1276 and upregulating sirtuin 4 (SIRT4) expression. In conclusion, circOMA1 may act as an oncogenic circRNA in BC via regulation of the miR‑1276/SIRT4 axis. |
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AbstractList | Mounting evidence has indicated that circular RNAs (circRNAs) serve essential roles in the tumorigenesis and development of various types of cancer. However, the biological functions and the underlying mechanisms of circRNAs in breast cancer (Bc) remain largely elusive. In the present study, the expression pattern of circRNAs in three pairs of Bc tissues and adjacent normal tissues was determined using a circRNA microarray. The expression and prognostic value of circOMA1 were evaluated by reverse transcription-quantitative PcR in 64 pairs of Bc tissues and adjacent normal tissues. Survival curves were generated by the Kaplan-Meier method, and statistical significance was estimated using the log-rank test. A series of in vitro functional experiments were then performed to investigate the role of circOMA1 in the tumorigenesis of Bc. The results revealed that the expression levels of circOMA1 were upregulated in BC tissues, and its expression was markedly associated with tumor size and lymph node metastasis. Receiver operating characteristic analysis demonstrated that the expression of circOMA1 could be used to discriminate between Bc tissues and adjacent normal tissues. Functionally, overexpression of circOMA1 promoted the viability, migration and invasion of BC cells, whereas circOMA1 knockdown had the opposite effect. Mechanistic investigations showed that circOMA1 promoted the progression of Bc by sponging microRNA (miR)-1276 and upregulating sirtuin 4 (SIRT4) expression. In conclusion, circOMA1 may act as an oncogenic circRNA in Bc via regulation of the miR-1276/SIRT4 axis. Mounting evidence has indicated that circular RNAs (circRNAs) serve essential roles in the tumorigenesis and development of various types of cancer. However, the biological functions and the underlying mechanisms of circRNAs in breast cancer (BC) remain largely elusive. In the present study, the expression pattern of circRNAs in three pairs of BC tissues and adjacent normal tissues was determined using a circRNA microarray. The expression and prognostic value of circOMA1 were evaluated by reverse transcription‑quantitative PCR in 64 pairs of BC tissues and adjacent normal tissues. Survival curves were generated by the Kaplan‑Meier method, and statistical significance was estimated using the log‑rank test. A series of functional experiments were then performed to investigate the role of circOMA1 in the tumorigenesis of BC. The results revealed that the expression levels of circOMA1 were upregulated in BC tissues, and its expression was markedly associated with tumor size and lymph node metastasis. Receiver operating characteristic analysis demonstrated that the expression of circOMA1 could be used to discriminate between BC tissues and adjacent normal tissues. Functionally, overexpression of circOMA1 promoted the viability, migration and invasion of BC cells, whereas circOMA1 knockdown had the opposite effect. Mechanistic investigations showed that circOMA1 promoted the progression of BC by sponging microRNA (miR)‑1276 and upregulating sirtuin 4 (SIRT4) expression. In conclusion, circOMA1 may act as an oncogenic circRNA in BC via regulation of the miR‑1276/SIRT4 axis. Mounting evidence has indicated that circular RNAs (circRNAs) serve essential roles in the tumorigenesis and development of various types of cancer. However, the biological functions and the underlying mechanisms of circRNAs in breast cancer (Bc) remain largely elusive. In the present study, the expression pattern of circRNAs in three pairs of Bc tissues and adjacent normal tissues was determined using a circRNA microarray. The expression and prognostic value of circOMA1 were evaluated by reverse transcription-quantitative PcR in 64 pairs of Bc tissues and adjacent normal tissues. Survival curves were generated by the Kaplan-Meier method, and statistical significance was estimated using the log-rank test. A series of in vitro functional experiments were then performed to investigate the role of circOMA1 in the tumorigenesis of Bc. The results revealed that the expression levels of circOMA1 were upregulated in BC tissues, and its expression was markedly associated with tumor size and lymph node metastasis. Receiver operating characteristic analysis demonstrated that the expression of circOMA1 could be used to discriminate between Bc tissues and adjacent normal tissues. Functionally, overexpression of circOMA1 promoted the viability, migration and invasion of BC cells, whereas circOMA1 knockdown had the opposite effect. Mechanistic investigations showed that circOMA1 promoted the progression of Bc by sponging microRNA (miR)-1276 and upregulating sirtuin 4 (SIRT4) expression. In conclusion, circOMA1 may act as an oncogenic circRNA in Bc via regulation of the miR-1276/SIRT4 axis. Key words: circular RNA OMA1, breast cancer, microRNA-1276, sirtuin 4 Mounting evidence has indicated that circular RNAs (circRNAs) serve essential roles in the tumorigenesis and development of various types of cancer. However, the biological functions and the underlying mechanisms of circRNAs in breast cancer (BC) remain largely elusive. In the present study, the expression pattern of circRNAs in three pairs of BC tissues and adjacent normal tissues was determined using a circRNA microarray. The expression and prognostic value of circOMA1 were evaluated by reverse transcription-quantitative PCR in 64 pairs of BC tissues and adjacent normal tissues. Survival curves were generated by the Kaplan-Meier method, and statistical significance was estimated using the log-rank test. A series of in vitro functional experiments were then performed to investigate the role of circOMA1 in the tumorigenesis of BC. The results revealed that the expression levels of circOMA1 were upregulated in BC tissues, and its expression was markedly associated with tumor size and lymph node metastasis. Receiver operating characteristic analysis demonstrated that the expression of circOMA1 could be used to discriminate between BC tissues and adjacent normal tissues. Functionally, overexpression of circOMA1 promoted the viability, migration and invasion of BC cells, whereas circOMA1 knockdown had the opposite effect. Mechanistic investigations showed that circOMA1 promoted the progression of BC by sponging microRNA (miR)-1276 and upregulating sirtuin 4 (SIRT4) expression. In conclusion, circOMA1 may act as an oncogenic circRNA in BC via regulation of the miR-1276/SIRT4 axis. |
ArticleNumber | 728 |
Audience | Academic |
Author | Xu, Lingli Xiang, Lijun Xu, Ke Yan, Jiamei |
AuthorAffiliation | 1 Department of Ultrasound, Ningbo Zhenghai Longsai Hospital, Ningbo, Zhejiang 315200, P.R. China 2 Department of Radiology, Ningbo Zhenghai Traditional Chinese Medicine Hospital, Ningbo, Zhejiang 315200, P.R. China 3 Department of Ultrasound, Ningbo Medical Center Lihuili Eastern Hospital, Ningbo, Zhejiang 315040, P.R. China |
AuthorAffiliation_xml | – name: 1 Department of Ultrasound, Ningbo Zhenghai Longsai Hospital, Ningbo, Zhejiang 315200, P.R. China – name: 2 Department of Radiology, Ningbo Zhenghai Traditional Chinese Medicine Hospital, Ningbo, Zhejiang 315200, P.R. China – name: 3 Department of Ultrasound, Ningbo Medical Center Lihuili Eastern Hospital, Ningbo, Zhejiang 315040, P.R. China |
Author_xml | – sequence: 1 givenname: Lingli surname: Xu fullname: Xu, Lingli organization: Department of Ultrasound, Ningbo Zhenghai Longsai Hospital, Ningbo, Zhejiang 315200, P.R. China – sequence: 2 givenname: Ke surname: Xu fullname: Xu, Ke organization: Department of Radiology, Ningbo Zhenghai Traditional Chinese Medicine Hospital, Ningbo, Zhejiang 315200, P.R. China – sequence: 3 givenname: Lijun surname: Xiang fullname: Xiang, Lijun organization: Department of Ultrasound, Ningbo Zhenghai Longsai Hospital, Ningbo, Zhejiang 315200, P.R. China – sequence: 4 givenname: Jiamei surname: Yan fullname: Yan, Jiamei organization: Department of Ultrasound, Ningbo Medical Center Lihuili Eastern Hospital, Ningbo, Zhejiang 315040, P.R. China |
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CitedBy_id | crossref_primary_10_14336_AD_2022_1123 crossref_primary_10_1016_j_ejphar_2023_175781 crossref_primary_10_3390_cancers14122952 crossref_primary_10_1111_jgh_16402 crossref_primary_10_1016_j_heliyon_2023_e22874 crossref_primary_10_1016_j_ncrna_2022_09_011 |
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Keywords | microRNA‑1276 breast cancer circular RNA OMA1 sirtuin 4 |
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Snippet | Mounting evidence has indicated that circular RNAs (circRNAs) serve essential roles in the tumorigenesis and development of various types of cancer. However,... |
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SubjectTerms | Adult Aged Apoptosis Biomarkers, Tumor - genetics Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer therapies Carcinogenesis - genetics Cell Line, Tumor Cell Movement Cell Survival Circular RNA Development and progression DNA microarrays Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Health aspects HEK293 Cells Humans Lymph nodes Metalloendopeptidases - genetics Metalloendopeptidases - metabolism Metastases Metastasis MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miRNA Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Physiological aspects Plasmids Prognosis Reverse transcription RNA RNA polymerase RNA, Circular Sirtuins - genetics Sirtuins - metabolism Tumorigenesis Young Adult |
Title | Circular RNA OMA1 regulates the progression of breast cancer via modulation of the miR‑1276/SIRT4 axis |
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