Association of Mannose-Binding Lectin Deficiency with Acute Invasive Aspergillosis in Immunocompromised Patients

• Published in: Clinical infectious diseases Vol. 49; no. 10; pp. 1486 - 1491
• Main Authors: Lambourne, Jonathan, Agranoff, Dan, Herbrecht, Raoul, Troke, Peter F., Buchbinder, Aby, Willis, Fenella, Letscher-Bru, Valérie, Agrawal, Samir, Doffman, Sarah, Johnson, Elizabeth, White, P. Lewis, Barnes, Rosemary A., Griffin, George, Lindsay, Jodi A., Harrison, Thomas S.
• Format: Journal Article
• Language: English
• Published: Oxford The University of Chicago Press 15.11.2009; University of Chicago Press; Oxford University Press
• Subjects: Adult; Animal models; Animals; Antifungals; ARTICLES AND COMMENTARIES; Aspergillosis; Aspergillosis - epidemiology; Aspergillosis - immunology; Aspergillus; Biological and medical sciences; Disease Susceptibility; Drug therapy; Enzyme-linked immunosorbent assay; Enzymes; Female; Fungi; Genes; Glycoproteins; Human mycoses; Humans; Immunocompromised Host; Immunocompromised hosts; Immunocompromised populations; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infection; Infections; Infectious diseases; Lectins; Male; Mannose-binding lectin; Mannose-Binding Lectin - blood; Mannose-Binding Lectin - deficiency; Medical sciences; Middle Aged; Miscellaneous mycoses; Mortality; Mycoses; Neutrophils; Pathogens; Pattern recognition; Prevalence; Respiratory diseases; Risk factors; Studies; Infection; Human; Immunopathology; Lectin; Mycosis; Acute; Deficiency; Aspergillosis; Mannose; Immune deficiency

Background. Invasive aspergillosis is a devastating infection with attributable mortality of 40% despite antifungal therapy. In animal models of aspergillosis, deficiency of mannose-binding lectin (MBL), a pattern recognition receptor that activates complement, is a susceptibility factor. MBL defici...