Genistein Enhances TRAIL-Mediated Apoptosis Through the Inhibition of XIAP and DcR1 in Colon Carcinoma Cells Treated with 5-Fluorouracil

• Published in: Turkish Journal of Pharmaceutical Sciences Vol. 21; no. 1; pp. 7 - 24
• Main Authors: ÇAL DOĞAN, Tuğbagül, AYDIN DİLSİZ, Sevtap, CANPINAR, Hande, ÜNDEĞER BUCURGAT, Ülkü
• Format: Journal Article
• Language: English
• Published: Turkey Galenos Yayinevi Tic. Ltd 01.02.2024; Galenos Publishing
• Subjects: Apoptosis; Cancer; Carcinoma; Chemotherapy; Epidemiology; Ethylenediaminetetraacetic acid; Fluorouracil; Isoflavones; Oncology, Experimental; Original; Pharmaceutical industry; Soybean; Tumor necrosis factor; United States; 5-fluorouracil; apoptosis; TRAIL; colorectal cancer; Genistein

Colorectal cancer is one of the most common cancers worldwide. However, surgical intervention and chemotherapy provide only limited benefits for the recovery and survival of patients. The anticarcinogenic effect of genistein has attracted attention because epidemiological studies have shown that soy...