Long non-coding RNA Xist contribution in systemic lupus erythematosus and rheumatoid arthritis

• Published in: Clinical immunology (Orlando, Fla.) Vol. 236; p. 108937
• Main Authors: Bost, Chloé, Arleevskaya, Marina I., Brooks, Wesley H., Plaza, Samuel, Guery, Jean-Charles, Renaudineau, Yves
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2022; Elsevier
• Subjects: Arthritis, Rheumatoid - genetics; Arthritis, Rheumatoid - metabolism; Female; Humans; Immunology; Interferon pathway; Life Sciences; Long non-coding RNA Xist; Lupus Erythematosus, Systemic - genetics; Lupus Erythematosus, Systemic - metabolism; MicroRNAs - genetics; Rheumatoid arthritis; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Synoviocytes - metabolism; Systemic lupus erythematosus; X chromosome; Systemic lupus erythematosus; Long non-coding RNA Xist; Rheumatoid arthritis; X chromosome; Interferon pathway

Growing evidence points towards the role of the long non-coding (lnc)-RNA Xist expressed in female cells as a predominant key actor for the sex bias observed in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Indeed, in female cells, lnc-Xist controls transcription directly by spre...