Pancreatic cancer in chronic pancreatitis; aetiology, incidence, and early detection

• Published in: Baillière's best practice & research. Clinical gastroenterology Vol. 24; no. 3; pp. 349 - 358
• Main Authors: Raimondi, Sara, Lowenfels, Albert B., Morselli-Labate, Antonio M., Maisonneuve, Patrick, Pezzilli, Raffaele
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.06.2010; Elsevier Limited
• Subjects: Acute pancreatitis; Adult; Cell Transformation, Neoplastic; Chronic illnesses; Chronic pancreatitis; Confidence intervals; Disease; Early Detection of Cancer; Epidemiology; Female; Gastroenterology and Hepatology; Hereditary pancreatitis; Humans; Incidence; Kras; Male; Mass Screening - methods; Middle Aged; Mortality; Mutation; Pancreas; Pancreatic cancer; Pancreatic Neoplasms - diagnosis; Pancreatic Neoplasms - epidemiology; Pancreatic Neoplasms - etiology; Pancreatitis; Pancreatitis, Chronic - complications; Pancreatitis, Chronic - epidemiology; Prognosis; Risk Assessment; Risk Factors; Rodents; Studies; Time Factors; Tropical pancreatitis; Tumors; Acute pancreatitis; Pancreatic cancer; Chronic pancreatitis; Pancreatitis; Tropical pancreatitis; Kras; Hereditary pancreatitis; Pancreas; Epidemiology

Acute pancreatitis, chronic pancreatitis and pancreatic cancer are responsible for most of the burden of exocrine pancreatic disease. Glandular damage from recurrent bouts of acute pancreatitis can lead to irreversible changes characteristic of chronic pancreatitis. In recent decades accumulating ev...