Longitudinal analysis of antibody dynamics in COVID-19 convalescents reveals neutralizing responses up to 16 months after infection

• Published in: Nature microbiology Vol. 7; no. 3; pp. 423 - 433
• Main Authors: Yang, Yang, Yang, Minghui, Peng, Yun, Liang, Yanhua, Wei, Jinli, Xing, Li, Guo, Liping, Li, Xiaohe, Li, Jie, Wang, Jun, Li, Mianhuan, Xu, Zhixiang, Zhang, Mingxia, Wang, Fuxiang, Shi, Yi, Yuan, Jing, Liu, Yingxia
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2022; Nature Publishing Group
• Subjects: 14/63; 38/1; 38/109; 631/250/255/2514; 631/326/596/4130; Adolescent; Adult; Aged; Antibodies; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antibodies, Viral - blood; Antibodies, Viral - immunology; Antibody response; Asymptomatic; Asymptomatic Infections - epidemiology; Biomedical and Life Sciences; Child; Child, Preschool; Cohort Studies; Coronaviruses; COVID-19; COVID-19 - blood; COVID-19 - epidemiology; COVID-19 - immunology; COVID-19 - virology; COVID-19 vaccines; Female; Humans; Immunoglobulin G; Immunoglobulin G - blood; Immunoglobulin G - immunology; Immunoglobulin M - blood; Immunoglobulin M - immunology; Infections; Infectious Diseases; Life Sciences; Male; Medical Microbiology; Microbiology; Middle Aged; Pandemics; Parasitology; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; SARS-CoV-2 - physiology; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; Vaccination; Virology; Young Adult

Elucidating the dynamics of the neutralizing antibody (nAb) response in coronavirus disease 2019 (COVID-19) convalescents is crucial in controlling the pandemic and informing vaccination strategies. Here we measured nAb titres across 411 sequential plasma samples collected during 1–480 d after illne...