Advances in enzymatic oxyfunctionalization of aliphatic compounds
Selective oxyfunctionalizations of aliphatic compounds are difficult chemical reactions, where enzymes can play an important role due to their stereo- and regio-selectivity and operation under mild reaction conditions. P450 monooxygenases are well-known biocatalysts that mediate oxyfunctionalization...
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| Published in | Biotechnology advances Vol. 51; p. 107703 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Inc
01.11.2021
Elsevier Science Ltd |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Selective oxyfunctionalizations of aliphatic compounds are difficult chemical reactions, where enzymes can play an important role due to their stereo- and regio-selectivity and operation under mild reaction conditions. P450 monooxygenases are well-known biocatalysts that mediate oxyfunctionalization reactions in different living organisms (from bacteria to humans). Unspecific peroxygenases (UPOs), discovered in fungi, have arisen as “dream biocatalysts” of great biotechnological interest because they catalyze the oxyfunctionalization of aliphatic and aromatic compounds, avoiding the necessity of expensive cofactors and regeneration systems, and only depending on H2O2 for their catalysis. Here, we summarize recent advances in aliphatic oxyfunctionalization reactions by UPOs, as well as the molecular determinants of the enzyme structures responsible for their activities, emphasizing the differences found between well-known P450s and the novel fungal peroxygenases. |
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| AbstractList | Selective oxyfunctionalizations of aliphatic compounds are difficult chemical reactions, where enzymes can play an important role due to their stereo- and regio-selectivity and operation under mild reaction conditions. P450 monooxygenases are well-known biocatalysts that mediate oxyfunctionalization reactions in different living organisms (from bacteria to humans). Unspecific peroxygenases (UPOs), discovered in fungi, have arisen as "dream biocatalysts" of great biotechnological interest because they catalyze the oxyfunctionalization of aliphatic and aromatic compounds, avoiding the necessity of expensive cofactors and regeneration systems, and only depending on H2O2 for their catalysis. Here, we summarize recent advances in aliphatic oxyfunctionalization reactions by UPOs, as well as the molecular determinants of the enzyme structures responsible for their activities, emphasizing the differences found between well-known P450s and the novel fungal peroxygenases. Selective oxyfunctionalizations of aliphatic compounds are difficult chemical reactions, where enzymes can play an important role due to their stereo- and regio-selectivity and operation under mild reaction conditions. P450 monooxygenases are well-known biocatalysts that mediate oxyfunctionalization reactions in different living organisms (from bacteria to humans). Unspecific peroxygenases (UPOs), discovered in fungi, have arisen as “dream biocatalysts” of great biotechnological interest because they catalyze the oxyfunctionalization of aliphatic and aromatic compounds, avoiding the necessity of expensive cofactors and regeneration systems, and only depending on H₂O₂ for their catalysis. Here, we summarize recent advances in aliphatic oxyfunctionalization reactions by UPOs, as well as the molecular determinants of the enzyme structures responsible for their activities, emphasizing the differences found between well-known P450s and the novel fungal peroxygenases. Selective oxyfunctionalizations of aliphatic compounds are difficult chemical reactions, where enzymes can play an important role due to their stereo- and regio-selectivity and operation under mild reaction conditions. P450 monooxygenases are well-known biocatalysts that mediate oxyfunctionalization reactions in different living organisms (from bacteria to humans). Unspecific peroxygenases (UPOs), discovered in fungi, have arisen as "dream biocatalysts" of great biotechnological interest because they catalyze the oxyfunctionalization of aliphatic and aromatic compounds, avoiding the necessity of expensive cofactors and regeneration systems, and only depending on H O for their catalysis. Here, we summarize recent advances in aliphatic oxyfunctionalization reactions by UPOs, as well as the molecular determinants of the enzyme structures responsible for their activities, emphasizing the differences found between well-known P450s and the novel fungal peroxygenases. Selective oxyfunctionalizations of aliphatic compounds are difficult chemical reactions, where enzymes can play an important role due to their stereo- and regio-selectivity and operation under mild reaction conditions. P450 monooxygenases are well-known biocatalysts that mediate oxyfunctionalization reactions in different living organisms (from bacteria to humans). Unspecific peroxygenases (UPOs), discovered in fungi, have arisen as "dream biocatalysts" of great biotechnological interest because they catalyze the oxyfunctionalization of aliphatic and aromatic compounds, avoiding the necessity of expensive cofactors and regeneration systems, and only depending on H2O2 for their catalysis. Here, we summarize recent advances in aliphatic oxyfunctionalization reactions by UPOs, as well as the molecular determinants of the enzyme structures responsible for their activities, emphasizing the differences found between well-known P450s and the novel fungal peroxygenases.Selective oxyfunctionalizations of aliphatic compounds are difficult chemical reactions, where enzymes can play an important role due to their stereo- and regio-selectivity and operation under mild reaction conditions. P450 monooxygenases are well-known biocatalysts that mediate oxyfunctionalization reactions in different living organisms (from bacteria to humans). Unspecific peroxygenases (UPOs), discovered in fungi, have arisen as "dream biocatalysts" of great biotechnological interest because they catalyze the oxyfunctionalization of aliphatic and aromatic compounds, avoiding the necessity of expensive cofactors and regeneration systems, and only depending on H2O2 for their catalysis. Here, we summarize recent advances in aliphatic oxyfunctionalization reactions by UPOs, as well as the molecular determinants of the enzyme structures responsible for their activities, emphasizing the differences found between well-known P450s and the novel fungal peroxygenases. |
| ArticleNumber | 107703 |
| Author | Carro, Juan Babot, Esteban D. Aranda, Carmen Linde, Dolores Martínez, Angel T. González-Benjumea, Alejandro Olmedo, Andrés Gutiérrez, Ana |
| Author_xml | – sequence: 1 givenname: Carmen surname: Aranda fullname: Aranda, Carmen organization: Instituto de Recursos Naturales y Agrobiología de Sevilla (IRNAS), CSIC, Reina Mercedes 10, 41012 Seville, Spain – sequence: 2 givenname: Juan surname: Carro fullname: Carro, Juan organization: Centro de Investigaciones Biológicas "Margarita Salas" (CIB), CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain – sequence: 3 givenname: Alejandro surname: González-Benjumea fullname: González-Benjumea, Alejandro organization: Instituto de Recursos Naturales y Agrobiología de Sevilla (IRNAS), CSIC, Reina Mercedes 10, 41012 Seville, Spain – sequence: 4 givenname: Esteban D. surname: Babot fullname: Babot, Esteban D. organization: Instituto de Recursos Naturales y Agrobiología de Sevilla (IRNAS), CSIC, Reina Mercedes 10, 41012 Seville, Spain – sequence: 5 givenname: Andrés surname: Olmedo fullname: Olmedo, Andrés organization: Instituto de Recursos Naturales y Agrobiología de Sevilla (IRNAS), CSIC, Reina Mercedes 10, 41012 Seville, Spain – sequence: 6 givenname: Dolores surname: Linde fullname: Linde, Dolores organization: Centro de Investigaciones Biológicas "Margarita Salas" (CIB), CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain – sequence: 7 givenname: Angel T. surname: Martínez fullname: Martínez, Angel T. email: atmartinez@cib.csic.es organization: Centro de Investigaciones Biológicas "Margarita Salas" (CIB), CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain – sequence: 8 givenname: Ana surname: Gutiérrez fullname: Gutiérrez, Ana email: anagu@irnase.csic.es organization: Instituto de Recursos Naturales y Agrobiología de Sevilla (IRNAS), CSIC, Reina Mercedes 10, 41012 Seville, Spain |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33545329$$D View this record in MEDLINE/PubMed |
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| Copyright | 2021 The Authors Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved. Copyright Elsevier Science Ltd. Nov 1, 2021 |
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| Keywords | Oxyfunctionalization Biocatalysis Hydroxylation UPO Terpenoids Epoxidation Alkanes P450 Peroxygenases Fatty acids |
| Language | English |
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| SubjectTerms | Aliphatic compounds Alkanes Aromatic compounds Biocatalysis Biocatalysts biotechnology catalytic activity Chemical compounds Chemical reactions enzymes Epoxidation Fatty acids fungi Hydrogen peroxide Hydroxylation Oxyfunctionalization P450 Peroxygenases Regeneration Selectivity Terpenoids UPO |
| Title | Advances in enzymatic oxyfunctionalization of aliphatic compounds |
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