Anti-HIV-1 activity and structure–activity-relationship study of a fucosylated glycosaminoglycan from an echinoderm by targeting the conserved CD4 induced epitope - Lian, Wu; Wu, Mingyi; Huang, Ning; Gao, Na; Xiao, Chuang; Li, Zi; Zhang, Zhigang; Zheng, Yongtang; Peng, Wenlie; Zhao, Jinhua (Biochimica et biophysica acta, 2013)
Keywords: Animals; Anti-HIV Agents - chemistry; Anti-HIV Agents - pharmacology; Anti-human immunodeficiency virus activity; anticoagulant activity; antiretroviral properties; binding capacity; Biolayer interferometry; CD4 Antigens - immunology; Cell Line; Cluster of Differentiation 4 induced epitope; cytopathogenicity; cytotoxicity; dextran; Echinodermata; Echinodermata - chemistry; Envelope glycoprotein 120; epitopes; Epitopes - immunology; fucose; Fucose - chemistry; Glycosaminoglycan; Glycosaminoglycans - chemistry; heparin; HIV Envelope Protein gp120 - metabolism; HIV infections; HIV-1 - drug effects; HIV-1 - physiology; Human immunodeficiency virus 1; Humans; interferometry; Molecular Weight; mononuclear leukocytes; Structure-Activity Relationship; structure-activity relationships; sulfates; Virus Replication - drug effects; HIV-1; FG; dFG; Mw; SA; Biolayer interferometry; APTT; Envelope glycoprotein 120; AR2G; Anti-human immunodeficiency virus activity; Glycosaminoglycan; Cluster of Differentiation 4 induced epitope; BLI; Structure–activity relationship; fucosylated glycosaminoglycan; molecular weight; human immunodeficiency virus type 1; Amine Reactive Second-Generation; activated partial thromboplastin time; depolymerized fucosylated glycosaminoglycan; streptavidin biosensors