Influence of folate status on genomic DNA methylation in colonic mucosa of subjects without colorectal adenoma or cancer

• Published in: British journal of cancer Vol. 92; no. 5; pp. 838 - 842
• Main Authors: Pufulete, M, Al-Ghnaniem, R, Rennie, J A, Appleby, P, Harris, N, Gout, S, Emery, P W, Sanders, T A
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.03.2005; Nature Publishing Group
• Subjects: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - genetics; Alcohol Drinking; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Clinical Study; Colon - cytology; Colon - enzymology; Colonoscopy; Colorectal cancer; Cystathionine beta-Synthase - genetics; DNA - genetics; DNA Methylation; Drug Resistance; Enzymes; Epidemiology; Erythrocytes - metabolism; Female; Folic Acid - blood; Gastroenterology. Liver. Pancreas. Abdomen; Genotype & phenotype; Homocysteine; Homocysteine - blood; Humans; Intestinal Mucosa - cytology; Intestinal Mucosa - enzymology; Leukocytes; Male; Medical research; Medical sciences; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Middle Aged; Molecular Medicine; Mutation; Oncology; Plasma; Polymorphism, Single Nucleotide; Reference Values; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumorigenesis; Tumors; Vitamin B; United Kingdom > UK; homocysteine; folate; colorectal cancer; CBS; MS; DNA methylation; MTHFR; genotype; Human; Rectal disease; Digestive system; Mucosa; Colorectal cancer; Malignant tumor; Folate; Colonic disease; Colorectal adenoma; Cancerology; Digestive diseases; Intestinal disease; Chromosome DNA; Benign neoplasm; Methylation

DNA hypomethylation may increase the risk of colorectal cancer. The main aim of this study was to assess the influence of folate status (serum and erythrocyte folate and plasma homocysteine concentrations) on DNA methylation. Methylenetetrahydrofolate reductase (MTHFR 677C → T and 1298A → C), methio...