The gut ileal mucosal virome is disturbed in patients with Crohn’s disease and exacerbates intestinal inflammation in mice

• Published in: Nature communications Vol. 15; no. 1; pp. 1638 - 22
• Main Authors: Cao, Zhirui, Fan, Dejun, Sun, Yang, Huang, Ziyu, Li, Yue, Su, Runping, Zhang, Feng, Li, Qing, Yang, Hongju, Zhang, Fen, Miao, Yinglei, Lan, Ping, Wu, Xiaojian, Zuo, Tao
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.02.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 14/19; 38/39; 45/22; 45/23; 45/77; 45/91; 64/60; 692/4020/2741/2135; 692/699/1503; Animal models; Bacteria; Crohn's disease; Digestive system; Dysbacteriosis; Gastrointestinal tract; Humanities and Social Sciences; Ileum; Inflammation; Inflammatory bowel disease; Inflammatory bowel diseases; Intestine; Microorganisms; Mucosal immunity; multidisciplinary; Pathogenesis; Phages; Remission; Science; Science (multidisciplinary); Small intestine; Virions

Gut bacteriome dysbiosis is known to be implicated in the pathogenesis of inflammatory bowel disease (IBD). Crohn’s disease (CD) is an IBD subtype with extensive mucosal inflammation, yet the mucosal virome, an empirical modulator of the bacteriome and mucosal immunity, remains largely unclear regar...