Identification and evaluation of magnolol and chrysophanol as the principle protein tyrosine phosphatase-1B inhibitory compounds in a Kampo medicine, Masiningan

• Published in: Journal of ethnopharmacology Vol. 186; no. NA; pp. 84 - 90
• Main Authors: Onoda, Toshihisa, Li, Wei, Sasaki, Tatsunori, Miyake, Megumi, Higai, Koji, Koike, Kazuo
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 20.06.2016
• Subjects: active ingredients; Anthraquinones - chemistry; Anthraquinones - pharmacology; bioactive compounds; Biphenyl Compounds - chemistry; Biphenyl Compounds - pharmacology; Catalytic Domain; chemical structure; Chrysophanol; computer simulation; constipation; diabetes mellitus; dose response; drugs; energy; high performance liquid chromatography; Humans; inhibitory concentration 50; insulin; Japan; Kampo medicine; Kinetics; Lignans - chemistry; Lignans - pharmacology; Magnolol; Masiningan; Medicine, Kampo; Models, Molecular; Molecular Structure; Protein Conformation; Protein tyrosine phosphatase 1B; Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors; signal transduction; spectral analysis; traditional medicine; tyrosine; VHR; Masiningan; TCPTP; Kampo medicine; pAkt; Magnolol; SHP-1; p-NP; p-NPP; PTP1B; SHP-2; Protein tyrosine phosphatase 1B; Chrysophanol

Masiningan is a traditional medicine consisting of six crude drugs that have been used for treating constipation and diabetes mellitus in both Japan and China. Masiningan has been reported to have significant PTP1B inhibitory activity and to affect cells in the insulin-signaling pathway. The aim of...