Identification and evaluation of magnolol and chrysophanol as the principle protein tyrosine phosphatase-1B inhibitory compounds in a Kampo medicine, Masiningan - Onoda, Toshihisa; Li, Wei; Sasaki, Tatsunori; Miyake, Megumi; Higai, Koji; Koike, Kazuo (Journal of ethnopharmacology, 2016)
Keywords: active ingredients; Anthraquinones - chemistry; Anthraquinones - pharmacology; bioactive compounds; Biphenyl Compounds - chemistry; Biphenyl Compounds - pharmacology; Catalytic Domain; chemical structure; Chrysophanol; computer simulation; constipation; diabetes mellitus; dose response; drugs; energy; high performance liquid chromatography; Humans; inhibitory concentration 50; insulin; Japan; Kampo medicine; Kinetics; Lignans - chemistry; Lignans - pharmacology; Magnolol; Masiningan; Medicine, Kampo; Models, Molecular; Molecular Structure; Protein Conformation; Protein tyrosine phosphatase 1B; Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors; signal transduction; spectral analysis; traditional medicine; tyrosine; VHR; Masiningan; TCPTP; Kampo medicine; pAkt; Magnolol; SHP-1; p-NP; p-NPP; PTP1B; SHP-2; Protein tyrosine phosphatase 1B; Chrysophanol