High prevalence of array comparative genomic hybridization abnormalities in adults with unexplained intellectual disability

• Published in: Genetics in medicine Vol. 12; no. 1; pp. 32 - 38
• Main Authors: Taylor, Matthew R.G., Jirikowic, Jean, Wells, Cara, Springer, Michelle, McGavran, Loris, Lunt, Brenda, Swisshelm, Karen
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01.01.2010; Nature Publishing Group US
• Subjects: Adult; adult genetic disorders; array comparative genomic hybridization; Biomedical and Life Sciences; Biomedicine; Comparative Genomic Hybridization - statistics & numerical data; Ethnicity; Female; Human Genetics; Humans; intellectual disability; Intellectual Disability - etiology; Intellectual Disability - genetics; Intelligence - genetics; Karyotyping; Laboratory Medicine; Male; mental retardation; Prevalence; Racial Groups; mental retardation; adult genetic disorders; array comparative genomic hybridization; intellectual disability

Array comparative genomic hybridization is now a widely used clinical tool for the evaluation of intellectual disability. The current 10% yield of positive findings is based largely on pediatric data. Adults with unexplained intellectual disability have not been systematically studied with array com...