Natural products for treatment of osteoporosis: The effects and mechanisms on promoting osteoblast-mediated bone formation

• Published in: Life sciences (1973) Vol. 147; pp. 46 - 58
• Main Authors: An, Jing, Yang, Hao, Zhang, Qian, Liu, Cuicui, Zhao, Jingjing, Zhang, Lingling, Chen, Bo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.02.2016
• Subjects: active ingredients; adverse effects; Animals; anthraquinones; Biological Products - pharmacology; Biological Products - therapeutic use; bone density; bone formation; bone resorption; Cell Differentiation - drug effects; Cell Proliferation - drug effects; coumarins; developmental orthopedic disease; diterpenoids; flavonoids; glycosides; Humans; Medicine, Chinese Traditional; mitogen-activated protein kinase; Molecular mechanism; monoterpenoids; Natural products; nitric oxide; Oriental traditional medicine; Osteoblasts; Osteoblasts - drug effects; Osteoblasts - metabolism; Osteogenesis - drug effects; Osteoporosis; Osteoporosis - drug therapy; Osteoporosis - physiopathology; phenolic acids; phenols; research and development; sesquiterpenoids; signal transduction; Traditional Chinese medicines; transcription (genetics); transcription factors; BMMSCs; Traditional Chinese medicines; NO; RANKL; Vanillic acid (PubChem CID): 8468; ALP; Icariin (PubChem CID): 5,318,997; Honokiol (PubChem CID): 72,303; JNK; Molecular mechanism; OPG; cGMP; RANK; MDA; OPN; C/EBP-β; Osteoblasts; sGC; Kirenol (PubChem CID): 15,736,732; Osteoporosis; MSCs; Psoralen (PubChem CID): 6199; PI3K; BMD; EREs; COL I; Puerarin (PubChem CID): 5,281,807; BSP; Runx2; MAPKs; ERs; Osthole (PubChem CID): 10,228; Cbfa1; PKC; PKG; COL1A1; BMPs; Genistein (PubChem CID): 5,280,961; NOS; Osx; Natural products; ROS; Naringin (PubChem CID): 442,428; OCN; BMSCs; Costunolide (PubChem CID): 5,281,437; ERK

Osteoporosis is a systemic metabolic bone disease characterized by a reduction in bone mass, bone quality, and microarchitectural deterioration. An imbalance in bone remodeling that is caused by more osteoclast-mediated bone resorption than osteoblast-mediated bone formation results in such patholog...