Natural products for treatment of osteoporosis: The effects and mechanisms on promoting osteoblast-mediated bone formation

Osteoporosis is a systemic metabolic bone disease characterized by a reduction in bone mass, bone quality, and microarchitectural deterioration. An imbalance in bone remodeling that is caused by more osteoclast-mediated bone resorption than osteoblast-mediated bone formation results in such patholog...

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Published in	Life sciences (1973) Vol. 147; pp. 46 - 58
Main Authors	An, Jing, Yang, Hao, Zhang, Qian, Liu, Cuicui, Zhao, Jingjing, Zhang, Lingling, Chen, Bo
Format	Journal Article
Language	English
Published	Netherlands Elsevier Inc 15.02.2016
Subjects	active ingredients adverse effects Animals anthraquinones Biological Products - pharmacology Biological Products - therapeutic use bone density bone formation bone resorption Cell Differentiation - drug effects Cell Proliferation - drug effects coumarins developmental orthopedic disease diterpenoids flavonoids glycosides Humans Medicine, Chinese Traditional mitogen-activated protein kinase Molecular mechanism monoterpenoids Natural products nitric oxide Oriental traditional medicine Osteoblasts Osteoblasts - drug effects Osteoblasts - metabolism Osteogenesis - drug effects Osteoporosis Osteoporosis - drug therapy Osteoporosis - physiopathology phenolic acids phenols research and development sesquiterpenoids signal transduction Traditional Chinese medicines transcription (genetics) transcription factors BMMSCs Traditional Chinese medicines NO RANKL Vanillic acid (PubChem CID): 8468 ALP Icariin (PubChem CID): 5,318,997 Honokiol (PubChem CID): 72,303 JNK Molecular mechanism OPG cGMP RANK MDA OPN C/EBP-β Osteoblasts sGC Kirenol (PubChem CID): 15,736,732 Osteoporosis MSCs Psoralen (PubChem CID): 6199 PI3K BMD EREs COL I Puerarin (PubChem CID): 5,281,807 BSP Runx2 MAPKs ERs Osthole (PubChem CID): 10,228 Cbfa1 PKC PKG COL1A1 BMPs Genistein (PubChem CID): 5,280,961 NOS Osx Natural products ROS Naringin (PubChem CID): 442,428 OCN BMSCs Costunolide (PubChem CID): 5,281,437 ERK
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Abstract	Osteoporosis is a systemic metabolic bone disease characterized by a reduction in bone mass, bone quality, and microarchitectural deterioration. An imbalance in bone remodeling that is caused by more osteoclast-mediated bone resorption than osteoblast-mediated bone formation results in such pathologic bone disorder. Traditional Chinese medicines (TCM) have long been used to prevent and treat osteoporosis and have received extensive attentions and researches at home and abroad, because they have fewer adverse reactions and are more suitable for long-term use compared with chemically synthesized medicines. Here, we put the emphasis on osteoblasts, summarized the detailed research progress on the active compounds derived from TCM with potential anti-osteoporosis effects and their molecular mechanisms on promoting osteoblast-mediated bone formation. It could be concluded that TCM with kidney-tonifying, spleen-tonifying, and stasis-removing effects all have the potential effects on treating osteoporosis. The active ingredients derived from TCM that possess effects on promoting osteoblasts proliferation and differentiation include flavonoids, glycosides, coumarins, terpenoids (sesquiterpenoids, monoterpenoids, diterpenoids), phenolic acids, phenols and others (tetrameric stilbene, anthraquinones, diarylheptanoids). And it was confirmed that the bone formation effect induced by the above natural products was regulated by the expressions of bone specific matrix proteins (ALP, BSP, OCN, OPN, COL I), transcription factor (Runx2, Cbfa1, Osx), signal pathways (MAPK, BMP), local factors (ROS, NO), OPG/RANKL system of osteoblasts and estrogen-like biological activities. All the studies provided theoretical basis for clinical application, as well as new drug research and development on treating osteoporosis. [Display omitted]
AbstractList	Osteoporosis is a systemic metabolic bone disease characterized by a reduction in bone mass, bone quality, and microarchitectural deterioration. An imbalance in bone remodeling that is caused by more osteoclast-mediated bone resorption than osteoblast-mediated bone formation results in such pathologic bone disorder. Traditional Chinese medicines (TCM) have long been used to prevent and treat osteoporosis and have received extensive attentions and researches at home and abroad, because they have fewer adverse reactions and are more suitable for long-term use compared with chemically synthesized medicines. Here, we put the emphasis on osteoblasts, summarized the detailed research progress on the active compounds derived from TCM with potential anti-osteoporosis effects and their molecular mechanisms on promoting osteoblast-mediated bone formation. It could be concluded that TCM with kidney-tonifying, spleen-tonifying, and stasis-removing effects all have the potential effects on treating osteoporosis. The active ingredients derived from TCM that possess effects on promoting osteoblasts proliferation and differentiation include flavonoids, glycosides, coumarins, terpenoids (sesquiterpenoids, monoterpenoids, diterpenoids), phenolic acids, phenols and others (tetrameric stilbene, anthraquinones, diarylheptanoids). And it was confirmed that the bone formation effect induced by the above natural products was regulated by the expressions of bone specific matrix proteins (ALP, BSP, OCN, OPN, COL I), transcription factor (Runx2, Cbfa1, Osx), signal pathways (MAPK, BMP), local factors (ROS, NO), OPG/RANKL system of osteoblasts and estrogen-like biological activities. All the studies provided theoretical basis for clinical application, as well as new drug research and development on treating osteoporosis. Osteoporosis is a systemic metabolic bone disease characterized by a reduction in bone mass, bone quality, and microarchitectural deterioration. An imbalance in bone remodeling that is caused by more osteoclast-mediated bone resorption than osteoblast-mediated bone formation results in such pathologic bone disorder. Traditional Chinese medicines (TCM) have long been used to prevent and treat osteoporosis and have received extensive attentions and researches at home and abroad, because they have fewer adverse reactions and are more suitable for long-term use compared with chemically synthesized medicines. Here, we put the emphasis on osteoblasts, summarized the detailed research progress on the active compounds derived from TCM with potential anti-osteoporosis effects and their molecular mechanisms on promoting osteoblast-mediated bone formation. It could be concluded that TCM with kidney-tonifying, spleen-tonifying, and stasis-removing effects all have the potential effects on treating osteoporosis. The active ingredients derived from TCM that possess effects on promoting osteoblasts proliferation and differentiation include flavonoids, glycosides, coumarins, terpenoids (sesquiterpenoids, monoterpenoids, diterpenoids), phenolic acids, phenols and others (tetrameric stilbene, anthraquinones, diarylheptanoids). And it was confirmed that the bone formation effect induced by the above natural products was regulated by the expressions of bone specific matrix proteins (ALP, BSP, OCN, OPN, COL I), transcription factor (Runx2, Cbfa1, Osx), signal pathways (MAPK, BMP), local factors (ROS, NO), OPG/RANKL system of osteoblasts and estrogen-like biological activities. All the studies provided theoretical basis for clinical application, as well as new drug research and development on treating osteoporosis.Osteoporosis is a systemic metabolic bone disease characterized by a reduction in bone mass, bone quality, and microarchitectural deterioration. An imbalance in bone remodeling that is caused by more osteoclast-mediated bone resorption than osteoblast-mediated bone formation results in such pathologic bone disorder. Traditional Chinese medicines (TCM) have long been used to prevent and treat osteoporosis and have received extensive attentions and researches at home and abroad, because they have fewer adverse reactions and are more suitable for long-term use compared with chemically synthesized medicines. Here, we put the emphasis on osteoblasts, summarized the detailed research progress on the active compounds derived from TCM with potential anti-osteoporosis effects and their molecular mechanisms on promoting osteoblast-mediated bone formation. It could be concluded that TCM with kidney-tonifying, spleen-tonifying, and stasis-removing effects all have the potential effects on treating osteoporosis. The active ingredients derived from TCM that possess effects on promoting osteoblasts proliferation and differentiation include flavonoids, glycosides, coumarins, terpenoids (sesquiterpenoids, monoterpenoids, diterpenoids), phenolic acids, phenols and others (tetrameric stilbene, anthraquinones, diarylheptanoids). And it was confirmed that the bone formation effect induced by the above natural products was regulated by the expressions of bone specific matrix proteins (ALP, BSP, OCN, OPN, COL I), transcription factor (Runx2, Cbfa1, Osx), signal pathways (MAPK, BMP), local factors (ROS, NO), OPG/RANKL system of osteoblasts and estrogen-like biological activities. All the studies provided theoretical basis for clinical application, as well as new drug research and development on treating osteoporosis. Osteoporosis is a systemic metabolic bone disease characterized by a reduction in bone mass, bone quality, and microarchitectural deterioration. An imbalance in bone remodeling that is caused by more osteoclast-mediated bone resorption than osteoblast-mediated bone formation results in such pathologic bone disorder. Traditional Chinese medicines (TCM) have long been used to prevent and treat osteoporosis and have received extensive attentions and researches at home and abroad, because they have fewer adverse reactions and are more suitable for long-term use compared with chemically synthesized medicines. Here, we put the emphasis on osteoblasts, summarized the detailed research progress on the active compounds derived from TCM with potential anti-osteoporosis effects and their molecular mechanisms on promoting osteoblast-mediated bone formation. It could be concluded that TCM with kidney-tonifying, spleen-tonifying, and stasis-removing effects all have the potential effects on treating osteoporosis. The active ingredients derived from TCM that possess effects on promoting osteoblasts proliferation and differentiation include flavonoids, glycosides, coumarins, terpenoids (sesquiterpenoids, monoterpenoids, diterpenoids), phenolic acids, phenols and others (tetrameric stilbene, anthraquinones, diarylheptanoids). And it was confirmed that the bone formation effect induced by the above natural products was regulated by the expressions of bone specific matrix proteins (ALP, BSP, OCN, OPN, COL I), transcription factor (Runx2, Cbfa1, Osx), signal pathways (MAPK, BMP), local factors (ROS, NO), OPG/RANKL system of osteoblasts and estrogen-like biological activities. All the studies provided theoretical basis for clinical application, as well as new drug research and development on treating osteoporosis. [Display omitted]
Author	Liu, Cuicui Zhao, Jingjing Yang, Hao Zhang, Qian An, Jing Chen, Bo Zhang, Lingling
Author_xml	– sequence: 1 givenname: Jing surname: An fullname: An, Jing email: anjing198812@126.com – sequence: 2 givenname: Hao surname: Yang fullname: Yang, Hao – sequence: 3 givenname: Qian surname: Zhang fullname: Zhang, Qian – sequence: 4 givenname: Cuicui surname: Liu fullname: Liu, Cuicui – sequence: 5 givenname: Jingjing surname: Zhao fullname: Zhao, Jingjing – sequence: 6 givenname: Lingling surname: Zhang fullname: Zhang, Lingling – sequence: 7 givenname: Bo surname: Chen fullname: Chen, Bo
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26796578$$D View this record in MEDLINE/PubMed
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Snippet	Osteoporosis is a systemic metabolic bone disease characterized by a reduction in bone mass, bone quality, and microarchitectural deterioration. An imbalance...
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SubjectTerms	active ingredients adverse effects Animals anthraquinones Biological Products - pharmacology Biological Products - therapeutic use bone density bone formation bone resorption Cell Differentiation - drug effects Cell Proliferation - drug effects coumarins developmental orthopedic disease diterpenoids flavonoids glycosides Humans Medicine, Chinese Traditional mitogen-activated protein kinase Molecular mechanism monoterpenoids Natural products nitric oxide Oriental traditional medicine Osteoblasts Osteoblasts - drug effects Osteoblasts - metabolism Osteogenesis - drug effects Osteoporosis Osteoporosis - drug therapy Osteoporosis - physiopathology phenolic acids phenols research and development sesquiterpenoids signal transduction Traditional Chinese medicines transcription (genetics) transcription factors
Title	Natural products for treatment of osteoporosis: The effects and mechanisms on promoting osteoblast-mediated bone formation
URI	https://dx.doi.org/10.1016/j.lfs.2016.01.024 https://www.ncbi.nlm.nih.gov/pubmed/26796578 https://www.proquest.com/docview/1767622441 https://www.proquest.com/docview/1805507475 https://www.proquest.com/docview/2101355819
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