High-resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson disease

• Published in: Neurology Vol. 72; no. 16; p. 1378
• Main Authors: Vaillancourt, D E, Spraker, M B, Prodoehl, J, Abraham, I, Corcos, D M, Zhou, X J, Comella, C L, Little, D M
• Format: Journal Article
• Language: English
• Published: United States 21.04.2009
• Subjects: Adult; Aged; Anisotropy; Biomarkers - analysis; Diagnosis, Differential; Diffusion; Diffusion Magnetic Resonance Imaging - instrumentation; Diffusion Magnetic Resonance Imaging - methods; Disease Progression; Dopamine - metabolism; Early Diagnosis; Female; Humans; Male; Middle Aged; Nerve Degeneration - diagnosis; Nerve Degeneration - physiopathology; Neurons - metabolism; Neurons - pathology; Parkinson Disease - diagnosis; Parkinson Disease - physiopathology; Predictive Value of Tests; Reproducibility of Results; Severity of Illness Index; Substantia Nigra - pathology; Substantia Nigra - physiopathology

In the midbrain of patients with Parkinson disease (PD), there is a selective loss of dopaminergic neurons in the ventrolateral and caudal substantia nigra (SN). In a mouse model of PD, investigators have administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and found that measures derive...