Altered neutrophil responses to dengue virus serotype three: delayed apoptosis is regulated by stabilisation of Mcl-1

• Published in: Scientific reports Vol. 14; no. 1; pp. 18414 - 10
• Main Authors: Kamsom, Chatcharin, Edwards, Steven W., Thaosing, Jiraphon, Papalee, Saitharn, Pientong, Chamsai, Kurosu, Takeshi, Phanthanawiboon, Supranee
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.08.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/2504/223/1699; 631/326/596/1413; Adaptive immunity; Apoptosis; Bcl-x protein; Cell Survival; CXCR4 protein; Dengue - immunology; Dengue - virology; Dengue fever; Dengue Virus - physiology; Global health; Granulocyte-macrophage colony-stimulating factor; Humanities and Social Sciences; Humans; Leukocyte migration; Leukocytes (neutrophilic); Life span; Lymph nodes; Mcl-1 protein; Monocyte chemoattractant protein 1; multidisciplinary; Myeloid Cell Leukemia Sequence 1 Protein - genetics; Myeloid Cell Leukemia Sequence 1 Protein - metabolism; Neutrophils; Neutrophils - immunology; Neutrophils - metabolism; Public health; Reactive oxygen species; Reactive Oxygen Species - metabolism; Science; Science (multidisciplinary); Serogroup; Tumor necrosis factor-α; Vector-borne diseases; Viruses

Dengue is a global health concern, and the host-viral interactions that regulate disease severity are largely unknown. Detrimental effects of neutrophils in this disease have been reported, but the precise mechanisms and functional properties of dengue-activated neutrophils are not fully characteris...