A negative feedback loop underlies the Warburg effect

• Published in: NPJ systems biology and applications Vol. 10; no. 1; pp. 55 - 9
• Main Authors: Jaiswal, Alok, Singh, Raghvendra
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.05.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/553; 631/67; Bioinformatics; Biomedical and Life Sciences; Cancer; Carcinogenesis; Cell cycle; Cell Cycle - physiology; Cell Line, Tumor; Cell proliferation; Cell Proliferation - physiology; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Feedback; Feedback, Physiological - physiology; Glycolysis; Glycolysis - physiology; Humans; Hypoxia; Lactic acid; Lactic Acid - metabolism; Life Sciences; Models, Biological; NAD - metabolism; Neoplasms - metabolism; Neoplastic Stem Cells - metabolism; Oxidative Phosphorylation; Phosphorylation; Systems Biology; Warburg Effect, Oncologic

Aerobic glycolysis, or the Warburg effect, is used by cancer cells for proliferation while producing lactate. Although lactate production has wide implications for cancer progression, it is not known how this effect increases cell proliferation and relates to oxidative phosphorylation. Here, we eluc...