A negative feedback loop underlies the Warburg effect

Aerobic glycolysis, or the Warburg effect, is used by cancer cells for proliferation while producing lactate. Although lactate production has wide implications for cancer progression, it is not known how this effect increases cell proliferation and relates to oxidative phosphorylation. Here, we eluc...

Full description

Saved in:
Bibliographic Details
Published inNPJ systems biology and applications Vol. 10; no. 1; pp. 55 - 9
Main Authors Jaiswal, Alok, Singh, Raghvendra
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 24.05.2024
Nature Publishing Group
Nature Portfolio
Subjects
631/553
631/67
Bioinformatics
Biomedical and Life Sciences
Cancer
Carcinogenesis
Cell cycle
Cell Cycle - physiology
Cell Line, Tumor
Cell proliferation
Cell Proliferation - physiology
Computational Biology/Bioinformatics
Computer Appl. in Life Sciences
Feedback
Feedback, Physiological - physiology
Glycolysis
Glycolysis - physiology
Humans
Hypoxia
Lactic acid
Lactic Acid - metabolism
Life Sciences
Models, Biological
NAD - metabolism
Neoplasms - metabolism
Neoplastic Stem Cells - metabolism
Oxidative Phosphorylation
Phosphorylation
Systems Biology
Warburg Effect, Oncologic
Online AccessGet full text

Cover

Abstract Aerobic glycolysis, or the Warburg effect, is used by cancer cells for proliferation while producing lactate. Although lactate production has wide implications for cancer progression, it is not known how this effect increases cell proliferation and relates to oxidative phosphorylation. Here, we elucidate that a negative feedback loop (NFL) is responsible for the Warburg effect. Further, we show that aerobic glycolysis works as an amplifier of oxidative phosphorylation. On the other hand, quiescence is an important property of cancer stem cells. Based on the NFL, we show that both aerobic glycolysis and oxidative phosphorylation, playing a synergistic role, are required to achieve cell quiescence. Further, our results suggest that the cells in their hypoxic niche are highly proliferative yet close to attaining quiescence by increasing their NADH/NAD+ ratio through the severity of hypoxia. The findings of this study can help in a better understanding of the link among metabolism, cell cycle, carcinogenesis, and stemness.
AbstractList Abstract Aerobic glycolysis, or the Warburg effect, is used by cancer cells for proliferation while producing lactate. Although lactate production has wide implications for cancer progression, it is not known how this effect increases cell proliferation and relates to oxidative phosphorylation. Here, we elucidate that a negative feedback loop (NFL) is responsible for the Warburg effect. Further, we show that aerobic glycolysis works as an amplifier of oxidative phosphorylation. On the other hand, quiescence is an important property of cancer stem cells. Based on the NFL, we show that both aerobic glycolysis and oxidative phosphorylation, playing a synergistic role, are required to achieve cell quiescence. Further, our results suggest that the cells in their hypoxic niche are highly proliferative yet close to attaining quiescence by increasing their NADH/NAD+ ratio through the severity of hypoxia. The findings of this study can help in a better understanding of the link among metabolism, cell cycle, carcinogenesis, and stemness.
Aerobic glycolysis, or the Warburg effect, is used by cancer cells for proliferation while producing lactate. Although lactate production has wide implications for cancer progression, it is not known how this effect increases cell proliferation and relates to oxidative phosphorylation. Here, we elucidate that a negative feedback loop (NFL) is responsible for the Warburg effect. Further, we show that aerobic glycolysis works as an amplifier of oxidative phosphorylation. On the other hand, quiescence is an important property of cancer stem cells. Based on the NFL, we show that both aerobic glycolysis and oxidative phosphorylation, playing a synergistic role, are required to achieve cell quiescence. Further, our results suggest that the cells in their hypoxic niche are highly proliferative yet close to attaining quiescence by increasing their NADH/NAD+ ratio through the severity of hypoxia. The findings of this study can help in a better understanding of the link among metabolism, cell cycle, carcinogenesis, and stemness.
Aerobic glycolysis, or the Warburg effect, is used by cancer cells for proliferation while producing lactate. Although lactate production has wide implications for cancer progression, it is not known how this effect increases cell proliferation and relates to oxidative phosphorylation. Here, we elucidate that a negative feedback loop (NFL) is responsible for the Warburg effect. Further, we show that aerobic glycolysis works as an amplifier of oxidative phosphorylation. On the other hand, quiescence is an important property of cancer stem cells. Based on the NFL, we show that both aerobic glycolysis and oxidative phosphorylation, playing a synergistic role, are required to achieve cell quiescence. Further, our results suggest that the cells in their hypoxic niche are highly proliferative yet close to attaining quiescence by increasing their NADH/NAD+ ratio through the severity of hypoxia. The findings of this study can help in a better understanding of the link among metabolism, cell cycle, carcinogenesis, and stemness.Aerobic glycolysis, or the Warburg effect, is used by cancer cells for proliferation while producing lactate. Although lactate production has wide implications for cancer progression, it is not known how this effect increases cell proliferation and relates to oxidative phosphorylation. Here, we elucidate that a negative feedback loop (NFL) is responsible for the Warburg effect. Further, we show that aerobic glycolysis works as an amplifier of oxidative phosphorylation. On the other hand, quiescence is an important property of cancer stem cells. Based on the NFL, we show that both aerobic glycolysis and oxidative phosphorylation, playing a synergistic role, are required to achieve cell quiescence. Further, our results suggest that the cells in their hypoxic niche are highly proliferative yet close to attaining quiescence by increasing their NADH/NAD+ ratio through the severity of hypoxia. The findings of this study can help in a better understanding of the link among metabolism, cell cycle, carcinogenesis, and stemness.
ArticleNumber 55
Author Jaiswal, Alok
Singh, Raghvendra
Author_xml – sequence: 1
  givenname: Alok
  surname: Jaiswal
  fullname: Jaiswal, Alok
  organization: Department of Chemical Engineering, Indian Institute of Technology Kanpur
– sequence: 2
  givenname: Raghvendra
  orcidid: 0000-0002-2398-8926
  surname: Singh
  fullname: Singh, Raghvendra
  email: raghvend@iitk.ac.in
  organization: Department of Chemical Engineering, Indian Institute of Technology Kanpur
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38789545$$D View this record in MEDLINE/PubMed
BookMark eNp9kUtv1TAQhS1UREvpH2CBIrFhE_A742VV8ahUqZtWXVq2M77kkhtf7ASVf4_blIK66Moj6ztnHuc1OZjShIS8ZfQjowI-FcmUpC3lsqVUdF17-4Iccap02zEwB__Vh-SklC2llGkhOaOvyKGADoyS6oio02bCjZuHX9hExN678KMZU9o3y9RjHgcszfwdmxuX_ZI3DcaIYX5DXkY3Fjx5eI_J9ZfPV2ff2ovLr-dnpxdtkKDmljmHnfdOcROM57QL6JVTwD2C1567ID3IjmmvjcEQ7zjmUALXMXQcxDE5X3375LZ2n4edy79tcoO9_0h5Y12ehzCiBe17rbURGI2EEByCClLHXgCggFi9Pqxe-5x-LlhmuxtKwHF0E6alWEF1vSuXQlf0_RN0m5Y81U0rpYzWTCleqXcP1OJ32D-O9_e4FeArEHIqJWN8RBi1dyHaNURbQ7T3IdrbKoInojDMNZ80zdkN4_NSsUpL7TNtMP8b-xnVH4pWrws
CitedBy_id crossref_primary_10_1016_j_biomaterials_2025_123164
crossref_primary_10_3390_cancers16234095
Cites_doi 10.1038/ncb3529
10.1038/s41586-022-05264-1
10.1016/j.tcb.2021.02.006
10.1038/sj.onc.1205859
10.1093/neuonc/not243
10.1016/j.dnarep.2016.04.008
10.1038/s41467-022-32448-0
10.1182/blood.2019003940
10.1016/j.bbabio.2012.01.014
10.1126/science.1160809
10.1038/nature16187
10.1016/j.molcel.2022.07.007
10.1038/s41571-018-0114-z
10.1038/s41388-020-01638-9
10.1126/science.123.3191.309
10.1038/s41577-019-0259-8
10.1016/j.stem.2008.11.006
10.1038/s41388-019-1060-7
10.1093/neuonc/nou112
10.1126/scisignal.aau9529
10.1242/dev.106575
10.1038/sj.neo.7900101
10.1126/science.1069300
10.1002/emmm.201201999
10.1038/ncb1010-924
10.1016/j.molcel.2010.05.023
10.1007/s10495-020-01648-8
10.1158/0008-5472.CAN-18-1886
10.1096/fj.04-2869fje
10.1038/onc.2010.191
10.1023/A:1023772912750
10.1189/jlb.0711386
10.1126/science.1250684
10.1007/s12015-016-9690-4
10.1126/science.1251086
10.1016/j.bbapap.2016.06.014
10.1038/nm.4409
10.1016/j.intimp.2006.08.011
10.1073/pnas.1213015110
10.1073/pnas.1633591100
10.1097/MPA.0000000000000103
10.1038/onc.2017.36
10.1016/j.stem.2017.04.011
10.1038/38291
10.1016/j.cell.2015.03.011
10.1016/j.bbcan.2023.188886
10.1038/366701a0
10.1155/2016/1740936
10.1016/j.celrep.2016.11.007
10.1158/0008-5472.CAN-10-1666
10.1016/j.ccell.2016.08.005
10.1007/s12015-020-10031-8
10.1038/ncomms6203
ContentType Journal Article
Copyright The Author(s) 2024
2024. The Author(s).
The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2024
– notice: 2024. The Author(s).
– notice: The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7X7
7XB
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M7P
PHGZM
PHGZT
PIMPY
PKEHL
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
7X8
DOA
DOI 10.1038/s41540-024-00377-x
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
ProQuest Health & Medical Collection (NC LIVE)
ProQuest Central (purchase pre-March 2016)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection (via ProQuest)
ProQuest Health & Medical Complete (Alumni)
ProQuest Biological Science Collection
ProQuest Health & Medical Collection
Biological Science Database
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
ProQuest One Applied & Life Sciences
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Central (New)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList

CrossRef
Publicly Available Content Database
MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 5
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2056-7189
EndPage 9
ExternalDocumentID oai_doaj_org_article_86bd66693ef948ccae85c46fd388e38f
38789545
10_1038_s41540_024_00377_x
Genre Journal Article
GroupedDBID 0R~
5VS
7X7
8FE
8FH
8FI
AAJSJ
AASML
ABUWG
ACGFS
ADBBV
AFKRA
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
C6C
EBLON
EBS
FYUFA
GROUPED_DOAJ
HCIFZ
HYE
KQ8
LK8
M7P
M~E
NAO
NO~
OK1
PGMZT
PIMPY
PQQKQ
PROAC
PUEGO
RNT
RPM
SNYQT
UKHRP
8FJ
AAYXX
CCPQU
CITATION
HMCUK
PHGZM
PHGZT
3V.
ACSMW
AJTQC
CGR
CUY
CVF
ECM
EIF
NPM
7XB
8FK
AARCD
AZQEC
DWQXO
GNUQQ
K9.
PKEHL
PQEST
PQGLB
PQUKI
PRINS
7X8
ID FETCH-LOGICAL-c485t-1aae7bba529c9b207ceb5a582be8b6b2ac4b84716b699ecf529c1ae4826fc7283
IEDL.DBID DOA
ISSN 2056-7189
IngestDate Wed Aug 27 01:28:50 EDT 2025
Mon Jul 21 11:11:36 EDT 2025
Wed Aug 13 04:11:40 EDT 2025
Thu Jan 02 22:34:40 EST 2025
Tue Jul 01 01:18:37 EDT 2025
Thu Apr 24 22:58:06 EDT 2025
Sun Aug 31 08:58:36 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License 2024. The Author(s).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c485t-1aae7bba529c9b207ceb5a582be8b6b2ac4b84716b699ecf529c1ae4826fc7283
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-2398-8926
OpenAccessLink https://doaj.org/article/86bd66693ef948ccae85c46fd388e38f
PMID 38789545
PQID 3059661552
PQPubID 2041915
PageCount 9
ParticipantIDs doaj_primary_oai_doaj_org_article_86bd66693ef948ccae85c46fd388e38f
proquest_miscellaneous_3060382436
proquest_journals_3059661552
pubmed_primary_38789545
crossref_primary_10_1038_s41540_024_00377_x
crossref_citationtrail_10_1038_s41540_024_00377_x
springer_journals_10_1038_s41540_024_00377_x
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2024-05-24
PublicationDateYYYYMMDD 2024-05-24
PublicationDate_xml – month: 05
  year: 2024
  text: 2024-05-24
  day: 24
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle NPJ systems biology and applications
PublicationTitleAbbrev npj Syst Biol Appl
PublicationTitleAlternate NPJ Syst Biol Appl
PublicationYear 2024
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Je, O, Ji, Cho, Lee (CR18) 2014; 43
Demir, Klein, Mandel-Molinas, Tuzuner (CR25) 2007; 7
Somasundaram (CR6) 1997; 389
García-Prat (CR44) 2016; 529
Pucci, Kasten, Giordano (CR54) 2000; 2
Rzymski (CR43) 2010; 29
Brisson (CR42) 2016; 30
Cheng (CR22) 2014; 345
Heiden, Cantley, Thompson (CR1) 2009; 324
Shibahara (CR31) 2015; 17
McConnell (CR14) 2016; 17
CR36
Pilié, Tang, Mills, Yap (CR10) 2018; 16
Chesnelong (CR29) 2014; 16
Lim (CR34) 2010; 38
Masuda, Togo, Mizuno, Konishi, Nanba (CR23) 2012; 91
Lee (CR40) 2015; 161
Hebert-Chatelain (CR16) 2012; 1817
Saeed (CR24) 2014; 345
Antonica (CR32) 2022; 13
Niu (CR19) 2002; 21
Xiong (CR53) 1993; 366
Warburg (CR2) 1956; 123
Gu (CR21) 2020; 136
Lee (CR39) 2013; 110
Sbrana (CR46) 2016; 12
Fjeld, Birdsong, Goodman (CR51) 2003; 100
Ansó (CR27) 2017; 19
Yu (CR7) 2019; 39
Nakamura-Ishizu, Takizawa, Suda (CR15) 2014; 141
Baixauli (CR26) 2022; 610
Liu (CR37) 2009; 4
Jaiswal, Singh (CR52) 2023; 1878
Zhu (CR49) 2021; 40
García-Prat, Sousa-Victor, Muñoz-Cánoves (CR47) 2017; 20
Chen, Dong, Haiech, Kilhoffer, Zeniou (CR13) 2016; 2016
Summy, Gallick (CR20) 2003; 22
Ancel, Stuelsatz, Feige (CR28) 2021; 31
Yang, Sauve (CR33) 2016; 1864
Ivashkiv (CR41) 2019; 20
Batlle, Clevers (CR11) 2017; 23
Pan, Cai, Li, Liu, Izpisua Belmonte (CR45) 2013; 5
van den Beucken (CR48) 2014; 5
Seltzer (CR30) 2010; 70
Hanse (CR5) 2017; 36
Karimian, Ahmadi, Yousefi (CR9) 2016; 42
Go, Kramer, Verhoeven, Oude Elferink, Chang (CR35) 2021; 26
Lee, Reed-Newman, Anant, Ramasamy (CR12) 2020; 16
Martin, Cano (CR50) 2010; 12
Zhang, Piston, Goodman (CR8) 2002; 295
La (CR38) 2018; 78
Birts (CR4) 2020; 13
Wang (CR3) 2022; 82
Krymskaya (CR17) 2005; 19
A Karimian (377_CR9) 2016; 42
JM Summy (377_CR20) 2003; 22
SC Cheng (377_CR22) 2014; 345
Y Xiong (377_CR53) 1993; 366
O Warburg (377_CR2) 1956; 123
G Niu (377_CR19) 2002; 21
Y Wang (377_CR3) 2022; 82
E Hebert-Chatelain (377_CR16) 2012; 1817
E Batlle (377_CR11) 2017; 23
H Pan (377_CR45) 2013; 5
DW Je (377_CR18) 2014; 43
G Demir (377_CR25) 2007; 7
F Antonica (377_CR32) 2022; 13
S Saeed (377_CR24) 2014; 345
T van den Beucken (377_CR48) 2014; 5
E Ansó (377_CR27) 2017; 19
S Ancel (377_CR28) 2021; 31
B Pucci (377_CR54) 2000; 2
Q Zhang (377_CR8) 2002; 295
MJ Seltzer (377_CR30) 2010; 70
DC Lee (377_CR40) 2015; 161
L García-Prat (377_CR44) 2016; 529
Y Yu (377_CR7) 2019; 39
S Go (377_CR35) 2021; 26
A Jaiswal (377_CR52) 2023; 1878
AM McConnell (377_CR14) 2016; 17
L Brisson (377_CR42) 2016; 30
K Somasundaram (377_CR6) 1997; 389
A Nakamura-Ishizu (377_CR15) 2014; 141
LB Ivashkiv (377_CR41) 2019; 20
SH Lee (377_CR12) 2020; 16
C Chesnelong (377_CR29) 2014; 16
JH Lim (377_CR34) 2010; 38
PG Pilié (377_CR10) 2018; 16
T Rzymski (377_CR43) 2010; 29
Y Masuda (377_CR23) 2012; 91
FV Sbrana (377_CR46) 2016; 12
W Chen (377_CR13) 2016; 2016
I Shibahara (377_CR31) 2015; 17
Y Liu (377_CR37) 2009; 4
VP Krymskaya (377_CR17) 2005; 19
Y Yang (377_CR33) 2016; 1864
P Zhu (377_CR49) 2021; 40
H Gu (377_CR21) 2020; 136
T La (377_CR38) 2018; 78
J Lee (377_CR39) 2013; 110
A Martin (377_CR50) 2010; 12
EA Hanse (377_CR5) 2017; 36
377_CR36
MGV Heiden (377_CR1) 2009; 324
CN Birts (377_CR4) 2020; 13
L García-Prat (377_CR47) 2017; 20
F Baixauli (377_CR26) 2022; 610
CC Fjeld (377_CR51) 2003; 100
References_xml – volume: 19
  start-page: 614
  year: 2017
  end-page: 625
  ident: CR27
  article-title: The mitochondrial respiratory chain is essential for haematopoietic stem cell function
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3529
– volume: 610
  start-page: 555
  year: 2022
  end-page: 561
  ident: CR26
  article-title: An LKB1-mitochondria axis controls TH17 effector function
  publication-title: Nature
  doi: 10.1038/s41586-022-05264-1
– volume: 31
  start-page: 556
  year: 2021
  end-page: 568
  ident: CR28
  article-title: Muscle Stem Cell Quiescence: Controlling Stemness by Staying Asleep
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2021.02.006
– volume: 21
  start-page: 7001
  year: 2002
  end-page: 7010
  ident: CR19
  article-title: Roles of activated Src and Stat3 signaling in melanoma tumor cell growth
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1205859
– volume: 16
  start-page: 686
  year: 2014
  end-page: 695
  ident: CR29
  article-title: Lactate dehydrogenase A silencing in IDH mutant gliomas
  publication-title: Neuro. Oncol.
  doi: 10.1093/neuonc/not243
– volume: 42
  start-page: 63
  year: 2016
  end-page: 71
  ident: CR9
  article-title: Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage
  publication-title: DNA Repair (Amst.)
  doi: 10.1016/j.dnarep.2016.04.008
– volume: 13
  start-page: 1
  year: 2022
  end-page: 15
  ident: CR32
  article-title: A slow-cycling/quiescent cells subpopulation is involved in glioma invasiveness
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-022-32448-0
– volume: 136
  start-page: 553
  year: 2020
  end-page: 571
  ident: CR21
  article-title: MDH1-mediated malate-aspartate NADH shuttle maintains the activity levels of fetal liver hematopoietic stem cells
  publication-title: Blood
  doi: 10.1182/blood.2019003940
– volume: 1817
  start-page: 718
  year: 2012
  end-page: 725
  ident: CR16
  article-title: Preservation of NADH ubiquinone-oxidoreductase activity by Src kinase-mediated phosphorylation of NDUFB10
  publication-title: Biochim. et. Biophys. Acta (BBA) - Bioenerg.
  doi: 10.1016/j.bbabio.2012.01.014
– volume: 324
  start-page: 1029
  year: 2009
  end-page: 1033
  ident: CR1
  article-title: Understanding the warburg effect: The metabolic requirements of cell proliferation
  publication-title: Science
  doi: 10.1126/science.1160809
– volume: 529
  start-page: 37
  year: 2016
  end-page: 42
  ident: CR44
  article-title: Autophagy maintains stemness by preventing senescence
  publication-title: Nature
  doi: 10.1038/nature16187
– volume: 82
  start-page: 3270
  year: 2022
  end-page: 3283.e9
  ident: CR3
  article-title: Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2022.07.007
– volume: 16
  start-page: 81
  year: 2018
  end-page: 104
  ident: CR10
  article-title: State-of-the-art strategies for targeting the DNA damage response in cancer
  publication-title: Nat. Rev. Clin. Oncol.
  doi: 10.1038/s41571-018-0114-z
– volume: 40
  start-page: 1609
  year: 2021
  end-page: 1627
  ident: CR49
  article-title: A novel hypoxic long noncoding RNA KB-1980E6.3 maintains breast cancer stem cell stemness via interacting with IGF2BP1 to facilitate c-Myc mRNA stability
  publication-title: Oncogene
  doi: 10.1038/s41388-020-01638-9
– volume: 123
  start-page: 309
  year: 1956
  end-page: 314
  ident: CR2
  article-title: On the origin of cancer cells
  publication-title: Science
  doi: 10.1126/science.123.3191.309
– volume: 20
  start-page: 85
  year: 2019
  end-page: 86
  ident: CR41
  article-title: The hypoxia–lactate axis tempers inflammation
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/s41577-019-0259-8
– volume: 4
  start-page: 37
  year: 2009
  end-page: 48
  ident: CR37
  article-title: p53 Regulates Hematopoietic Stem Cell Quiescence
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2008.11.006
– ident: CR36
– volume: 39
  start-page: 1273
  year: 2019
  end-page: 1289
  ident: CR7
  article-title: RBBP8/CtIP suppresses P21 expression by interacting with CtBP and BRCA1 in gastric cancer
  publication-title: Oncogene
  doi: 10.1038/s41388-019-1060-7
– volume: 17
  start-page: 136
  year: 2015
  end-page: 144
  ident: CR31
  article-title: Malignant clinical features of anaplastic gliomas without IDH mutation
  publication-title: Neuro. Oncol.
  doi: 10.1093/neuonc/nou112
– volume: 13
  start-page: eaau9529
  year: 2020
  ident: CR4
  article-title: p53 is regulated by aerobic glycolysis in cancer cells by the CtBP family of NADH-dependent transcriptional regulators
  publication-title: Sci. Signal
  doi: 10.1126/scisignal.aau9529
– volume: 5
  start-page: 1
  year: 2014
  end-page: 13
  ident: CR48
  article-title: Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER
  publication-title: Nat. Commun.
– volume: 141
  start-page: 4656
  year: 2014
  end-page: 4666
  ident: CR15
  article-title: The analysis, roles and regulation of quiescence in hematopoietic stem cells
  publication-title: Development
  doi: 10.1242/dev.106575
– volume: 2
  start-page: 291
  year: 2000
  end-page: 299
  ident: CR54
  article-title: Cell Cycle and Apoptosis
  publication-title: Neoplasia
  doi: 10.1038/sj.neo.7900101
– volume: 295
  start-page: 1895
  year: 2002
  end-page: 1897
  ident: CR8
  article-title: Regulation of corepressor function by nuclear NADH
  publication-title: Science
  doi: 10.1126/science.1069300
– volume: 5
  start-page: 327
  year: 2013
  end-page: 331
  ident: CR45
  article-title: Autophagic control of cell ‘stemness’
  publication-title: EMBO Mol. Med
  doi: 10.1002/emmm.201201999
– volume: 12
  start-page: 924
  year: 2010
  end-page: 925
  ident: CR50
  article-title: Tumorigenesis: Twist1 links EMT to self-renewal
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1010-924
– volume: 38
  start-page: 864
  year: 2010
  end-page: 878
  ident: CR34
  article-title: Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2010.05.023
– volume: 26
  start-page: 38
  year: 2021
  end-page: 51
  ident: CR35
  article-title: The extracellular lactate-to-pyruvate ratio modulates the sensitivity to oxidative stress-induced apoptosis via the cytosolic NADH/NAD+ redox state
  publication-title: Apoptosis
  doi: 10.1007/s10495-020-01648-8
– volume: 78
  start-page: 6666
  year: 2018
  end-page: 6679
  ident: CR38
  article-title: A p53-responsive miRNA network promotes cancer cell quiescence
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-18-1886
– volume: 19
  start-page: 1
  year: 2005
  end-page: 20
  ident: CR17
  article-title: Src is necessary and sufficient for human airway smooth muscle cell proliferation and migration
  publication-title: FASEB J.
  doi: 10.1096/fj.04-2869fje
– volume: 29
  start-page: 4424
  year: 2010
  end-page: 4435
  ident: CR43
  article-title: Regulation of autophagy by ATF4 in response to severe hypoxia
  publication-title: Oncogene
  doi: 10.1038/onc.2010.191
– volume: 22
  start-page: 337
  year: 2003
  end-page: 358
  ident: CR20
  article-title: Src family kinases in tumor progression and metastasis
  publication-title: Cancer Metast. Rev.
  doi: 10.1023/A:1023772912750
– volume: 91
  start-page: 547
  year: 2012
  end-page: 556
  ident: CR23
  article-title: Soluble β-glucan from Grifola frondosa induces proliferation and Dectin-1/Syk signaling in resident macrophages via the GM-CSF autocrine pathway
  publication-title: J. Leukoc. Biol.
  doi: 10.1189/jlb.0711386
– volume: 345
  start-page: 1250684
  year: 2014
  ident: CR22
  article-title: MTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity
  publication-title: Science
  doi: 10.1126/science.1250684
– volume: 12
  start-page: 621
  year: 2016
  end-page: 633
  ident: CR46
  article-title: The Role of Autophagy in the Maintenance of Stemness and Differentiation of Mesenchymal Stem Cells
  publication-title: Stem Cell Rev. Rep.
  doi: 10.1007/s12015-016-9690-4
– volume: 345
  start-page: 1251086
  year: 2014
  ident: CR24
  article-title: Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity
  publication-title: Science
  doi: 10.1126/science.1251086
– volume: 1864
  start-page: 1787
  year: 2016
  ident: CR33
  article-title: NAD+ metabolism: Bioenergetics, signaling and manipulation for therapy
  publication-title: Biochim Biophys. Acta
  doi: 10.1016/j.bbapap.2016.06.014
– volume: 23
  start-page: 1124
  year: 2017
  end-page: 1134
  ident: CR11
  article-title: Cancer stem cells revisited
  publication-title: Nat. Med.
  doi: 10.1038/nm.4409
– volume: 7
  start-page: 113
  year: 2007
  end-page: 116
  ident: CR25
  article-title: Beta glucan induces proliferation and activation of monocytes in peripheral blood of patients with advanced breast cancer
  publication-title: Int Immunopharmacol.
  doi: 10.1016/j.intimp.2006.08.011
– volume: 110
  start-page: 4634
  year: 2013
  end-page: 4639
  ident: CR39
  article-title: Runx1 and p21 synergistically limit the extent of hair follicle stem cell quiescence in vivo
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1213015110
– volume: 100
  start-page: 9202
  year: 2003
  end-page: 9207
  ident: CR51
  article-title: Differential binding of NAD+ and NADH allows the transcriptional corepressor carboxyl-terminal binding protein to serve as a metabolic sensor
  publication-title: Proc. Natl Acad. Sci.
  doi: 10.1073/pnas.1633591100
– volume: 43
  start-page: 768
  year: 2014
  end-page: 776
  ident: CR18
  article-title: The inhibition of Src family kinase suppresses pancreatic cancer cell proliferation, migration, and invasion
  publication-title: Pancreas
  doi: 10.1097/MPA.0000000000000103
– volume: 36
  start-page: 3915
  year: 2017
  end-page: 3924
  ident: CR5
  article-title: Cytosolic malate dehydrogenase activity helps support glycolysis in actively proliferating cells and cancer
  publication-title: Oncogene
  doi: 10.1038/onc.2017.36
– volume: 20
  start-page: 593
  year: 2017
  end-page: 608
  ident: CR47
  article-title: Proteostatic and Metabolic Control of Stemness
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2017.04.011
– volume: 389
  start-page: 187
  year: 1997
  end-page: 190
  ident: CR6
  article-title: Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1
  publication-title: Nature
  doi: 10.1038/38291
– volume: 161
  start-page: 595
  year: 2015
  end-page: 609
  ident: CR40
  article-title: A Lactate-Induced Response to Hypoxia
  publication-title: Cell
  doi: 10.1016/j.cell.2015.03.011
– volume: 1878
  start-page: 188886
  year: 2023
  ident: CR52
  article-title: CtBP: A global regulator of balancing acts and homeostases
  publication-title: Biochim. et. Biophys. Acta (BBA) - Rev. Cancer
  doi: 10.1016/j.bbcan.2023.188886
– volume: 366
  start-page: 701
  year: 1993
  end-page: 704
  ident: CR53
  article-title: p21 is a universal inhibitor of cyclin kinases
  publication-title: Nature
  doi: 10.1038/366701a0
– volume: 2016
  start-page: 1740936
  year: 2016
  ident: CR13
  article-title: Cancer stem cell quiescence and plasticity as major challenges in cancer therapy
  publication-title: Stem Cells Int
  doi: 10.1155/2016/1740936
– volume: 17
  start-page: 2173
  year: 2016
  end-page: 2182
  ident: CR14
  article-title: p53 Regulates Progenitor Cell Quiescence and Differentiation in the Airway
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.11.007
– volume: 70
  start-page: 8981
  year: 2010
  end-page: 8987
  ident: CR30
  article-title: Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-10-1666
– volume: 30
  start-page: 418
  year: 2016
  end-page: 431
  ident: CR42
  article-title: Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2016.08.005
– volume: 16
  start-page: 1185
  year: 2020
  end-page: 1207
  ident: CR12
  article-title: Regulatory Role of Quiescence in the Biological Function of Cancer Stem Cells
  publication-title: Stem Cell Rev. Rep.
  doi: 10.1007/s12015-020-10031-8
– volume: 16
  start-page: 1185
  year: 2020
  ident: 377_CR12
  publication-title: Stem Cell Rev. Rep.
  doi: 10.1007/s12015-020-10031-8
– volume: 17
  start-page: 2173
  year: 2016
  ident: 377_CR14
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.11.007
– volume: 5
  start-page: 1
  year: 2014
  ident: 377_CR48
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms6203
– volume: 36
  start-page: 3915
  year: 2017
  ident: 377_CR5
  publication-title: Oncogene
  doi: 10.1038/onc.2017.36
– volume: 43
  start-page: 768
  year: 2014
  ident: 377_CR18
  publication-title: Pancreas
  doi: 10.1097/MPA.0000000000000103
– volume: 23
  start-page: 1124
  year: 2017
  ident: 377_CR11
  publication-title: Nat. Med.
  doi: 10.1038/nm.4409
– volume: 30
  start-page: 418
  year: 2016
  ident: 377_CR42
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2016.08.005
– volume: 26
  start-page: 38
  year: 2021
  ident: 377_CR35
  publication-title: Apoptosis
  doi: 10.1007/s10495-020-01648-8
– volume: 1817
  start-page: 718
  year: 2012
  ident: 377_CR16
  publication-title: Biochim. et. Biophys. Acta (BBA) - Bioenerg.
  doi: 10.1016/j.bbabio.2012.01.014
– ident: 377_CR36
– volume: 13
  start-page: 1
  year: 2022
  ident: 377_CR32
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-022-32448-0
– volume: 29
  start-page: 4424
  year: 2010
  ident: 377_CR43
  publication-title: Oncogene
  doi: 10.1038/onc.2010.191
– volume: 17
  start-page: 136
  year: 2015
  ident: 377_CR31
  publication-title: Neuro. Oncol.
  doi: 10.1093/neuonc/nou112
– volume: 22
  start-page: 337
  year: 2003
  ident: 377_CR20
  publication-title: Cancer Metast. Rev.
  doi: 10.1023/A:1023772912750
– volume: 529
  start-page: 37
  year: 2016
  ident: 377_CR44
  publication-title: Nature
  doi: 10.1038/nature16187
– volume: 31
  start-page: 556
  year: 2021
  ident: 377_CR28
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2021.02.006
– volume: 19
  start-page: 1
  year: 2005
  ident: 377_CR17
  publication-title: FASEB J.
  doi: 10.1096/fj.04-2869fje
– volume: 110
  start-page: 4634
  year: 2013
  ident: 377_CR39
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1213015110
– volume: 13
  start-page: eaau9529
  year: 2020
  ident: 377_CR4
  publication-title: Sci. Signal
  doi: 10.1126/scisignal.aau9529
– volume: 610
  start-page: 555
  year: 2022
  ident: 377_CR26
  publication-title: Nature
  doi: 10.1038/s41586-022-05264-1
– volume: 295
  start-page: 1895
  year: 2002
  ident: 377_CR8
  publication-title: Science
  doi: 10.1126/science.1069300
– volume: 82
  start-page: 3270
  year: 2022
  ident: 377_CR3
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2022.07.007
– volume: 1864
  start-page: 1787
  year: 2016
  ident: 377_CR33
  publication-title: Biochim Biophys. Acta
  doi: 10.1016/j.bbapap.2016.06.014
– volume: 366
  start-page: 701
  year: 1993
  ident: 377_CR53
  publication-title: Nature
  doi: 10.1038/366701a0
– volume: 20
  start-page: 593
  year: 2017
  ident: 377_CR47
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2017.04.011
– volume: 1878
  start-page: 188886
  year: 2023
  ident: 377_CR52
  publication-title: Biochim. et. Biophys. Acta (BBA) - Rev. Cancer
  doi: 10.1016/j.bbcan.2023.188886
– volume: 345
  start-page: 1250684
  year: 2014
  ident: 377_CR22
  publication-title: Science
  doi: 10.1126/science.1250684
– volume: 42
  start-page: 63
  year: 2016
  ident: 377_CR9
  publication-title: DNA Repair (Amst.)
  doi: 10.1016/j.dnarep.2016.04.008
– volume: 40
  start-page: 1609
  year: 2021
  ident: 377_CR49
  publication-title: Oncogene
  doi: 10.1038/s41388-020-01638-9
– volume: 39
  start-page: 1273
  year: 2019
  ident: 377_CR7
  publication-title: Oncogene
  doi: 10.1038/s41388-019-1060-7
– volume: 20
  start-page: 85
  year: 2019
  ident: 377_CR41
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/s41577-019-0259-8
– volume: 2
  start-page: 291
  year: 2000
  ident: 377_CR54
  publication-title: Neoplasia
  doi: 10.1038/sj.neo.7900101
– volume: 123
  start-page: 309
  year: 1956
  ident: 377_CR2
  publication-title: Science
  doi: 10.1126/science.123.3191.309
– volume: 161
  start-page: 595
  year: 2015
  ident: 377_CR40
  publication-title: Cell
  doi: 10.1016/j.cell.2015.03.011
– volume: 5
  start-page: 327
  year: 2013
  ident: 377_CR45
  publication-title: EMBO Mol. Med
  doi: 10.1002/emmm.201201999
– volume: 16
  start-page: 81
  year: 2018
  ident: 377_CR10
  publication-title: Nat. Rev. Clin. Oncol.
  doi: 10.1038/s41571-018-0114-z
– volume: 70
  start-page: 8981
  year: 2010
  ident: 377_CR30
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-10-1666
– volume: 12
  start-page: 924
  year: 2010
  ident: 377_CR50
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1010-924
– volume: 389
  start-page: 187
  year: 1997
  ident: 377_CR6
  publication-title: Nature
  doi: 10.1038/38291
– volume: 100
  start-page: 9202
  year: 2003
  ident: 377_CR51
  publication-title: Proc. Natl Acad. Sci.
  doi: 10.1073/pnas.1633591100
– volume: 16
  start-page: 686
  year: 2014
  ident: 377_CR29
  publication-title: Neuro. Oncol.
  doi: 10.1093/neuonc/not243
– volume: 345
  start-page: 1251086
  year: 2014
  ident: 377_CR24
  publication-title: Science
  doi: 10.1126/science.1251086
– volume: 141
  start-page: 4656
  year: 2014
  ident: 377_CR15
  publication-title: Development
  doi: 10.1242/dev.106575
– volume: 136
  start-page: 553
  year: 2020
  ident: 377_CR21
  publication-title: Blood
  doi: 10.1182/blood.2019003940
– volume: 78
  start-page: 6666
  year: 2018
  ident: 377_CR38
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-18-1886
– volume: 19
  start-page: 614
  year: 2017
  ident: 377_CR27
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3529
– volume: 7
  start-page: 113
  year: 2007
  ident: 377_CR25
  publication-title: Int Immunopharmacol.
  doi: 10.1016/j.intimp.2006.08.011
– volume: 12
  start-page: 621
  year: 2016
  ident: 377_CR46
  publication-title: Stem Cell Rev. Rep.
  doi: 10.1007/s12015-016-9690-4
– volume: 21
  start-page: 7001
  year: 2002
  ident: 377_CR19
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1205859
– volume: 4
  start-page: 37
  year: 2009
  ident: 377_CR37
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2008.11.006
– volume: 38
  start-page: 864
  year: 2010
  ident: 377_CR34
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2010.05.023
– volume: 324
  start-page: 1029
  year: 2009
  ident: 377_CR1
  publication-title: Science
  doi: 10.1126/science.1160809
– volume: 91
  start-page: 547
  year: 2012
  ident: 377_CR23
  publication-title: J. Leukoc. Biol.
  doi: 10.1189/jlb.0711386
– volume: 2016
  start-page: 1740936
  year: 2016
  ident: 377_CR13
  publication-title: Stem Cells Int
  doi: 10.1155/2016/1740936
SSID ssj0001634210
Score 2.2844827
Snippet Aerobic glycolysis, or the Warburg effect, is used by cancer cells for proliferation while producing lactate. Although lactate production has wide implications...
Abstract Aerobic glycolysis, or the Warburg effect, is used by cancer cells for proliferation while producing lactate. Although lactate production has wide...
SourceID doaj
proquest
pubmed
crossref
springer
SourceType Open Website
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 55
SubjectTerms 631/553
631/67
Bioinformatics
Biomedical and Life Sciences
Cancer
Carcinogenesis
Cell cycle
Cell Cycle - physiology
Cell Line, Tumor
Cell proliferation
Cell Proliferation - physiology
Computational Biology/Bioinformatics
Computer Appl. in Life Sciences
Feedback
Feedback, Physiological - physiology
Glycolysis
Glycolysis - physiology
Humans
Hypoxia
Lactic acid
Lactic Acid - metabolism
Life Sciences
Models, Biological
NAD - metabolism
Neoplasms - metabolism
Neoplastic Stem Cells - metabolism
Oxidative Phosphorylation
Phosphorylation
Systems Biology
Warburg Effect, Oncologic
SummonAdditionalLinks – databaseName: ProQuest Health & Medical Collection (NC LIVE)
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB5BERIXxJu0BRmJG1hN_IpzQgVRVUhwomJvlu119kCVbHe3Uvn3zDjeXSGgUk7JJHLm4Znx2N8AvKWzlKQoXMVguUqEAamkQsPDPGxe4xUpUfz6zZxfqC8zPSsLbuuyrXI7J-aJej5GWiM_kdQnhopo4sPyilPXKKqulhYad-EeQZeRVrezdr_GYqTClKaclamlPVmjv6L9jEJxQl5p-c0f_ijD9v8r1vyrTprdz9kjeFjiRnY6Cfox3EnDE7g_dZL89RT0KRvSIoN4sx4dUvDxJ7scxyWjQ2IrDDTXDEM99sMTFxds2sbxDC7OPn__dM5LRwQeldUb3nif2hC8Fl3sgqjbmIL22oqQbDBB-KgCuRsTTNel2BNd45PCHKKPLUYSz-FgGIf0ElhoEmakSTexq1XsvUdzjD4kraKoQ1dX0Gz54mKBC6euFZcul62ldRMvHfLSZV66mwre7d5ZTmAZt1J_JHbvKAnoOt8YVwtX7MZZE-aYYXUy9ahUqG7J6qhMP5fWJmn7Co63wnLF-tZurysVvNk9RruhYogf0nhNNAaHJZQ0FbyYhLwbibSt7TC0rOD9Vur7j___hw5vH8sRPBBZ8TQX6hgONqvr9Aojmk14ndX2NzcT75Q
  priority: 102
  providerName: ProQuest
– databaseName: Springer Nature HAS Fully OA
  dbid: AAJSJ
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3di9RADA_HHYIv4rfVU0bwTYvtfHX6uIrHsaAvenhvw8xsug8e7bG7B-d_bzJt9xBPQehTm5ZpkmmSJvkF4A33UrKilDpFV2pkDEitNG08isNWFR2JA8XPX-zpmV6em_MDkHMvTC7az5CW-TM9V4e935Kh4UJEqUuGTGlK8huPGKqddPtosVh-Xd78WbFKUyAzdchUyt1y829WKIP13-Zh_pEdzUbn5D7cm7xFsRjX9wAOsH8Id8b5kT8fgVmIHtcZult0ZIZiSD_ExTBcCm4N25B7uRXk4InvgXm3FmPxxmM4O_n07eNpOc1BKJN2ZlfWIWATYzCyTW2UVZMwmmCcjOiijTIkHdnI2GjbFlPHdHVATZFDlxryH57AYT_0-AxErJHiUDR1aiuduhBoE6YQ0egkq9hWBdQzX3yaQMJ5VsWFz8lq5fzIS0-89JmX_rqAt_t7LkeIjH9Sf2B27ykZ3jqfGDZrP4nbOxtXFFe1CjtSJVIydCZp262Uc6hcV8DxLCw_7bmtVzxJiNOssoDX-8u0WzgFEnocrpjG0rKkVraAp6OQ9ytRrnEtOZQFvJulfvPwv7_Q8_8jfwF3ZVZEU0p9DIe7zRW-JL9mF19NivwLa3nvKQ
  priority: 102
  providerName: Springer Nature
Title A negative feedback loop underlies the Warburg effect
URI https://link.springer.com/article/10.1038/s41540-024-00377-x
https://www.ncbi.nlm.nih.gov/pubmed/38789545
https://www.proquest.com/docview/3059661552
https://www.proquest.com/docview/3060382436
https://doaj.org/article/86bd66693ef948ccae85c46fd388e38f
Volume 10
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3da9wwDBdbx2AvpR_7SNsdHvRtC038FefxerSUg5axrezejO1z-rCSK70rtP99JSd3bdnWvQwCgURxbMmKfopsCWCf9lLSRMll8CaXkXJASiFR8dAPmxZ4BHIUT8_0ybkcT9TkUakvWhPWpQfuGHdgtJ8ixK5FbLBVfF80KkjdTIUxUZiGvr5o8x45U-nvihYSnZl-l0whzMEcLRWtZOQyp5wrVX77xBKlhP1_Qpm_RUiT4TnegPUeMbJh19NNeBHbLXjd1ZC82wY1ZG28SOm7WYOmyLvwi13OZleMtoddI8ScMwR57Kcj_l2wbgHHWzg_PvoxOsn7Wgh5kEYt8tK5WHnvFK9D7XlRheiVU4b7aLz23AXpydBor-s6hoboShcleg9NqBBDvIO1dtbGD8B8GdEXjaoMdSFD4xwqYnA-Khl44esig3LJFxv6ROFUr-LSpoC1MLbjpUVe2sRLe5vB59UzV12ajGepD4ndK0pKcZ0uoOBtL3j7L8FnsLcUlu31bm4FVROiUCvP4NPqNmoMhUFcG2c3RKOxW1wKncH7TsirnghTmRpBZQZfllJ_aPzvA9r5HwPahTc8TU-Vc7kHa4vrm_gREc_CD-BlNakG8Go4HH8f4_nw6OzrN7w60qNBmvj3IdH9xA
linkProvider Directory of Open Access Journals
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VIgQXxJtAASPBCaImfsU5IFQe1ZY-Tq3Ym7G9zh6okmV3K9o_xW9kJo9dIaC3Sjklk8iZ-cYz47FnAF7RWUoCSiqDN6mMVANSComKh3HYJMMrUKB4eKRHJ_LLWI034NdwFoa2VQ5zYjtRT5pAa-TbgvrEUBKNv5_9SKlrFGVXhxYaHSz248VPDNkW7_Y-oXxfc777-fjjKO27CqRBGrVMc-di4b1TvAyl51kRoldOGe6j8dpzF6SnKVt7XZYxVESXuyjRD69CgdYYv3sNrqPhzSjYK8bFek1HC4khVH82JxNme4H2kfZPcplSpZciPf_D_rVtAv7l2_6Vl23N3e4duN37qWynA9Zd2Ij1PbjRda68uA9qh9Vx2hYNZxUaQO_Cd3baNDNGh9Lm6NguGLqW7KsjqU1Zt23kAZxcCa8ewmbd1PExMJ9HjICjykOZyVA5h-ofnI9KBp75MksgH_hiQ1-enLpknNo2TS6M7XhpkZe25aU9T-DN6p1ZV5zjUuoPxO4VJRXWbm8086nt9dQa7ScY0ZUiVghihHc0KkhdTYQxUZgqga1BWLbX9oVdYzOBl6vHqKeUfHF1bM6IRuOwuBQ6gUedkFcjEaYwJbqyCbwdpL7--P9_6MnlY3kBN0fHhwf2YO9o_ync4i0IVcrlFmwu52fxGXpTS_-8hTCDb1etM78BymIt1A
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR3LbtNAcFRSgbgg3hgKLBKcwIq9D3t9QKiljVoKUYWo6G3Z3axzoLJDkor21_g6ZvxIhIDeKvlkj631PHZmdl4AL6mWkhgllt7pWAbqASmFRMFDP2yS4OXJUfw0zvaP5YcTdbIBv_paGEqr7PfEZqOe1J7OyIeC5sRQEI0Pyy4t4mh39G72I6YJUhRp7cdptCxyGC5-ovu2eHuwi7R-xflo78v7_bibMBB7qdUyTq0NuXNW8cIXjie5D05ZpbkL2mWOWy8dbd-Zy4oi-JLgUhsk2uSlz1Ez43evwWZOXtEANnf2xkef1yc8mZDoUHWVOonQwwVqS8qm5DKmvi95fP6HNmyGBvzL0v0rStsov9FtuNVZrWy7ZbM7sBGqu3C9nWN5cQ_UNqvCtGkhzkpUh8767-y0rmeMStTmaOYuGBqa7KslGk5Zm0RyH46vBFsPYFDVVXgEzKUB_eGgUl8k0pfW4mbgrQtKep64Iokg7fFifNesnGZmnJomaC60aXFpEJemwaU5j-D16p1Z26rjUugdQvcKktpsNzfq-dR0Umt05ibo3xUilMjSyOxBKy-zciK0DkKXEWz1xDKd7C_MmlMjeLF6jFJLoRhbhfqMYDJcFpcii-BhS-TVSoTOdYGGbQRveqqvP_7_H3p8-Vqeww2UF_PxYHz4BG7yhgdVzOUWDJbzs_AUTaule9bxMINvVy02vwEc-jNv
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+negative+feedback+loop+underlies+the+Warburg+effect&rft.jtitle=NPJ+systems+biology+and+applications&rft.au=Alok+Jaiswal&rft.au=Raghvendra+Singh&rft.date=2024-05-24&rft.pub=Nature+Portfolio&rft.eissn=2056-7189&rft.volume=10&rft.issue=1&rft.spage=1&rft.epage=9&rft_id=info:doi/10.1038%2Fs41540-024-00377-x&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_86bd66693ef948ccae85c46fd388e38f
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2056-7189&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2056-7189&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2056-7189&client=summon