Cross-species spill-over potential of the H9N2 bat influenza A virus

• Published in: Nature communications Vol. 15; no. 1; pp. 3449 - 12
• Main Authors: El-Shesheny, Rabeh, Franks, John, Kandeil, Ahmed, Badra, Rebecca, Turner, Jasmine, Seiler, Patrick, Marathe, Bindumadhav M., Jeevan, Trushar, Kercher, Lisa, Hu, Meng, Sim, Yul Eum, Hui, Kenrie P. Y., Chan, Michael C. W., Thompson, Andrew J., McKenzie, Pamela, Govorkova, Elena A., Russell, Charles J., Vogel, Peter, Paulson, James C., Peiris, J. S. Malik, Webster, Robert G., Ali, Mohamed A., Kayali, Ghazi, Webby, Richard J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.04.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/21; 13/51; 45/77; 45/88; 45/90; 631/1647/334/1874/345; 631/326/421; 631/326/596/1578; 631/326/596/2563; 64; 64/60; Airborne infection; Animals; Aquatic birds; Avian flu; Chiroptera - virology; Ducks - virology; Exo-a-sialidase; Female; Ferrets - virology; Humanities and Social Sciences; Humans; Inactivation; Influenza; Influenza A; Influenza A Virus, H9N2 Subtype - isolation & purification; Influenza A Virus, H9N2 Subtype - pathogenicity; Influenza A Virus, H9N2 Subtype - physiology; Influenza in Birds - transmission; Influenza in Birds - virology; Influenza, Human - transmission; Influenza, Human - virology; Lung - virology; Lungs; Male; Males; Mice; multidisciplinary; Mustela; Neuraminidase - metabolism; Orthomyxoviridae; Orthomyxoviridae Infections - transmission; Orthomyxoviridae Infections - virology; Receptors; Receptors, Cell Surface; Respiratory tract; Science; Science (multidisciplinary); Virus Replication; Viruses; Egypt

In 2017, a novel influenza A virus (IAV) was isolated from an Egyptian fruit bat. In contrast to other bat influenza viruses, the virus was related to avian A(H9N2) viruses and was probably the result of a bird-to-bat transmission event. To determine the cross-species spill-over potential, we biolog...