Expression of matrix macromolecules and functional properties of breast cancer cells are modulated by the bisphosphonate zoledronic acid

• Published in: Biochimica et biophysica acta Vol. 1820; no. 12; pp. 1926 - 1939
• Main Authors: Dedes, P.G., Gialeli, Ch, Tsonis, A.I., Kanakis, I., Theocharis, A.D., Kletsas, D., Tzanakakis, G.N., Karamanos, N.K.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2012
• Subjects: Adhesion; antineoplastic agents; Blotting, Western; Bone Density Conservation Agents - pharmacology; Breast cancer; breast neoplasms; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; cell adhesion; Cell Adhesion - drug effects; Cell Movement - drug effects; Cell Proliferation - drug effects; Diphosphonates - pharmacology; Extracellular matrix; Extracellular Matrix - metabolism; Extracellular Matrix Proteins - genetics; Extracellular Matrix Proteins - metabolism; Female; functional properties; gene expression; Gene Expression Regulation, Neoplastic - drug effects; heparan sulfate; Humans; hyaluronic acid; Imidazoles - pharmacology; integrins; Invasion; metalloproteinases; metastasis; Migration; neoplasm cells; proteoglycans; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Tumor Cells, Cultured; Wound Healing - drug effects; Zoledronate; LN; BPs; Migration; FN; Breast cancer; COL-IV; Zoledronate; Adhesion; ECM; Invasion; MT-MMP; COL II; MMP; FAK; ZOL; PG; VN; HA; TIMPs; Extracellular matrix; TN; COL I; PKCa

The extracellular matrix (ECM) components play key roles in the multistep process of cancer growth and progression. Preclinical and clinical data show that bisphosphonates (BPs) may exert direct or indirect antitumoral effects. Despite proven efficiency in cancer treatment, the mechanism by which BP...