Cross‐talks between cyclooxygenase‐2 and tumor suppressor protein p53: Balancing life and death during inflammatory stress and carcinogenesis

• Published in: International journal of cancer Vol. 121; no. 5; pp. 929 - 937
• Main Authors: de Moraes, Emanuela, Dar, Nazir Ahmad, de Moura Gallo, Claudia Vitoria, Hainaut, Pierre
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2007; Wiley-Liss
• Subjects: Animals; apoptosis; Biological and medical sciences; cancer; Cell Transformation, Neoplastic; COX‐2; COX‐2 inhibitors; Cyclooxygenase 2 - metabolism; DNA damage; Humans; inflammation; Inflammation - metabolism; Medical sciences; p53; Tumor Suppressor Protein p53 - metabolism; Tumors; COX-2 inhibitors; COX-2; Enzyme; Cyclooxygenase 2; Mortality; p53 Protein; DNA damage; Inflammation; Cyclooxygenase 2 inhibitor; Malignant tumor; Carcinogenesis; Stress; p53; Cancerology; TP53 Gene; Cell death; Oxidoreductases; Lesion; Apoptosis; Tumor suppressor gene; Cancer

Overexpression of Cyclooxygenase‐2 (COX‐2) is observed in most tumor types. Increased COX‐2 activity and synthesis of prostaglandins stimulates proliferation, angiogenesis, invasiveness and inhibits apoptosis. Many stress and proinflammatory signals induce COX‐2 expression, including oxyradicals or...