Cross‐talks between cyclooxygenase‐2 and tumor suppressor protein p53: Balancing life and death during inflammatory stress and carcinogenesis
Overexpression of Cyclooxygenase‐2 (COX‐2) is observed in most tumor types. Increased COX‐2 activity and synthesis of prostaglandins stimulates proliferation, angiogenesis, invasiveness and inhibits apoptosis. Many stress and proinflammatory signals induce COX‐2 expression, including oxyradicals or...
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Published in | International journal of cancer Vol. 121; no. 5; pp. 929 - 937 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.09.2007
Wiley-Liss |
Subjects | |
Online Access | Get full text |
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