Nanoparticles Synergize Ferroptosis and Cuproptosis to Potentiate Cancer Immunotherapy

• Published in: Advanced science Vol. 11; no. 23; pp. e2310309 - n/a
• Main Authors: Li, Youyou, Liu, Jing, Chen, Yimei, Weichselbaum, Ralph R., Lin, Wenbin
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.06.2024; John Wiley and Sons Inc; Wiley
• Subjects: Animals; Cancer therapies; Cell death; Cell Line, Tumor; Copper; cuproptosis; Disease Models, Animal; Female; Ferroptosis; Ferroptosis - drug effects; Humans; Immunotherapy; Immunotherapy - methods; Lipid peroxidation; Lipids; Metabolism; Mice; Microemulsions; Nanoparticles; Piperazines; Proteins; Triple Negative Breast Neoplasms - drug therapy; Triple Negative Breast Neoplasms - immunology; Tumors; ferroptosis; nanoparticles; cuproptosis; immunotherapy

The recent discovery of copper‐mediated and mitochondrion‐dependent cuproptosis has aroused strong interest in harnessing this novel mechanism of cell death for cancer therapy. Here the design of a core‐shell nanoparticle, CuP/Er, for the co‐delivery of copper (Cu) and erastin (Er) to cancer cells f...