Identification of transcription factors expressed during ATRA‐induced neutrophil differentiation of HL60 cells

• Published in: British journal of haematology Vol. 103; no. 1; pp. 87 - 92
• Main Authors: MILLS, K. I, WALSH, V, GILKES, A. F, WOODGATE, L. J, BROWN, G, BURNETT, A. K
• Format: Journal Article
• Language: English
• Published: Oxford, U.K. and Cambridge, USA Blackwell Science Ltd 01.10.1998; Blackwell; Blackwell Publishing Ltd
• Subjects: Antineoplastic agents; ATRA; Biological and medical sciences; Cell Differentiation - drug effects; Clone Cells; degenerate PCR; General aspects; Hematology; HL-60 Cells; Humans; Medical sciences; neutrophil differentiation; Neutrophils - drug effects; Neutrophils - pathology; Pharmacology. Drug treatments; Reverse Transcriptase Polymerase Chain Reaction - methods; Transcription Factors; Tretinoin - pharmacology; Zinc Fingers; Antineoplastic agent; Human; Promyelocytic leukemia; Zinc finger structure; Acute; Granulocyte; Malignant hemopathy; Retinoids; Cell differentiation; HL60 cell line; Homeotic gene; Established cell line; Genetics; Neutrophil; POU Domain; Transcription factor; Tretinoin

A recent clinical therapeutic initiative has been the use of chemical agents which induce the leukaemic cells to overcome their block in differentiation. In order to understand this block the cascade of molecular events needs to be characterized. Haemopoietic differentiation is ultimately controlled...