The Impact of Patient Age and Corticosteroids in Patients With Sulfonamide Hepatotoxicity

• Published in: The American journal of gastroenterology Vol. 118; no. 9; pp. 1566 - 1575
• Main Authors: Fontana, Robert J., Kleiner, David E., Chalasani, Naga, Bonkovsky, Herbert, Gu, Jiezhun, Barnhart, Huiman, Li, Yi-Ju, Hoofnagle, Jay H.
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer 01.09.2023; Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
• Subjects: Adrenal Cortex Hormones - therapeutic use; Age; Antibiotics; Bilirubin; Causality; Chemical and Drug Induced Liver Injury - epidemiology; Chemical and Drug Induced Liver Injury - etiology; Cholestasis - pathology; Female; Hepatitis; Humans; Laboratories; Liver transplants; Male; Patients; Risk factors; Steroids; Sulfanilamide - adverse effects; Trimethoprim, Sulfamethoxazole Drug Combination - adverse effects; United States > US

Sulfonamides are widely used to treat and prevent various bacterial and opportunistic infections. The aim of this study was to describe the clinical presentation and outcomes of a large cohort of patients with sulfonamide hepatotoxicity. Between 2004 and 2020, 105 patients with hepatotoxicity attrib...