Celecoxib inhibits metabolism of cytochrome P450 2D6 substrate metoprolol in humans - Werner, Ulrike; Werner, Dierk; Rau, Thomas; Fromm, Martin F; Hinz, Burkhard; Brune, Kay (Clinical pharmacology and therapeutics, 2003)
Keywords: Adrenergic beta-Antagonists - pharmacokinetics; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases - genetics; Aryl Hydrocarbon Hydroxylases - metabolism; Biotransformation; Celecoxib; Cross-Over Studies; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors - pharmacology; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6 - genetics; Cytochrome P-450 CYP2D6 Inhibitors; Double-Blind Method; Genotype; Humans; Isoenzymes - metabolism; Lactones - pharmacology; Male; Membrane Proteins; Metoprolol - pharmacokinetics; Prostaglandin-Endoperoxide Synthases - metabolism; Pyrazoles; Sulfonamides - pharmacology; Sulfones