Burden of encephalitis-associated hospitalizations in the United States, 1998-2010

To estimate the burden of encephalitis-associated hospitalizations in the United States for 1998-2010. Using the Nationwide Inpatient Sample, a nationally representative database of hospitalizations, estimated numbers and rates of encephalitis-associated hospitalizations for 1998-2010 were calculate...

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Published inNeurology Vol. 82; no. 5; p. 443
Main Authors Vora, Neil M, Holman, Robert C, Mehal, Jason M, Steiner, Claudia A, Blanton, Jesse, Sejvar, James
Format Journal Article
LanguageEnglish
Published United States 04.02.2014
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Abstract To estimate the burden of encephalitis-associated hospitalizations in the United States for 1998-2010. Using the Nationwide Inpatient Sample, a nationally representative database of hospitalizations, estimated numbers and rates of encephalitis-associated hospitalizations for 1998-2010 were calculated. Etiology and outcome of encephalitis-associated hospitalizations were examined, as well as accompanying diagnoses listed along with encephalitis on the discharge records. Total hospital charges (in 2010 US dollars) were assessed. An estimated 263,352 (standard error: 3,017) encephalitis-associated hospitalizations occurred in the United States during 1998-2010, which corresponds to an average of 20,258 (standard error: 232) encephalitis-associated hospitalizations per year. A fatal outcome occurred in 5.8% (95% confidence interval [CI]: 5.6%-6.0%) of all encephalitis-associated hospitalizations and in 10.1% (95% CI: 9.2%-11.2%) and 17.1% (95% CI: 14.6%-20.0%) of encephalitis-associated hospitalizations in which a code for HIV or a tissue or organ transplant was listed, respectively. The proportion of encephalitis-associated hospitalizations in which an etiology for encephalitis was specified was 50.3% (95% CI: 49.6%-51.0%) and that for which the etiology was unspecified was 49.7% (95% CI: 49.0%-50.4%). Total charges for encephalitis-associated hospitalizations in 2010 were an estimated $2.0 billion. Encephalitis remains a major public health concern in the United States. Among the large number of encephalitis-associated hospitalizations for which an etiology is not reported may be novel infectious and noninfectious forms of encephalitis. Associated conditions such as HIV or transplantation increase the risk of a fatal outcome from an encephalitis-associated hospitalization and should be monitored.
AbstractList To estimate the burden of encephalitis-associated hospitalizations in the United States for 1998-2010. Using the Nationwide Inpatient Sample, a nationally representative database of hospitalizations, estimated numbers and rates of encephalitis-associated hospitalizations for 1998-2010 were calculated. Etiology and outcome of encephalitis-associated hospitalizations were examined, as well as accompanying diagnoses listed along with encephalitis on the discharge records. Total hospital charges (in 2010 US dollars) were assessed. An estimated 263,352 (standard error: 3,017) encephalitis-associated hospitalizations occurred in the United States during 1998-2010, which corresponds to an average of 20,258 (standard error: 232) encephalitis-associated hospitalizations per year. A fatal outcome occurred in 5.8% (95% confidence interval [CI]: 5.6%-6.0%) of all encephalitis-associated hospitalizations and in 10.1% (95% CI: 9.2%-11.2%) and 17.1% (95% CI: 14.6%-20.0%) of encephalitis-associated hospitalizations in which a code for HIV or a tissue or organ transplant was listed, respectively. The proportion of encephalitis-associated hospitalizations in which an etiology for encephalitis was specified was 50.3% (95% CI: 49.6%-51.0%) and that for which the etiology was unspecified was 49.7% (95% CI: 49.0%-50.4%). Total charges for encephalitis-associated hospitalizations in 2010 were an estimated $2.0 billion. Encephalitis remains a major public health concern in the United States. Among the large number of encephalitis-associated hospitalizations for which an etiology is not reported may be novel infectious and noninfectious forms of encephalitis. Associated conditions such as HIV or transplantation increase the risk of a fatal outcome from an encephalitis-associated hospitalization and should be monitored.
Author Steiner, Claudia A
Mehal, Jason M
Vora, Neil M
Sejvar, James
Holman, Robert C
Blanton, Jesse
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  organization: From the Epidemic Intelligence Service (N.M.V.) and Division of High-Consequence Pathogens and Pathology (N.M.V., R.C.H., J.M.M., J.B., J.S.), Centers for Disease Control and Prevention, Atlanta, GA; and Healthcare Cost and Utilization Project (C.A.S.), Center for Delivery, Organizations, and Markets, Agency for Healthcare Research and Quality, US Department of Health and Human Services, Rockville, MD
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  givenname: Jesse
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/24384647$$D View this record in MEDLINE/PubMed
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Snippet To estimate the burden of encephalitis-associated hospitalizations in the United States for 1998-2010. Using the Nationwide Inpatient Sample, a nationally...
SourceID pubmed
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StartPage 443
SubjectTerms Adolescent
Adult
Aged
Child
Child, Preschool
Cost of Illness
Databases, Factual - trends
Encephalitis - diagnosis
Encephalitis - economics
Encephalitis - epidemiology
Female
Health Care Costs - trends
Hospitalization - economics
Hospitalization - trends
Humans
Infant
Male
Middle Aged
United States - epidemiology
Young Adult
Title Burden of encephalitis-associated hospitalizations in the United States, 1998-2010
URI https://www.ncbi.nlm.nih.gov/pubmed/24384647
Volume 82
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