Altered patterns of transcription of the septin gene, SEPT9, in ovarian tumorigenesis

• Published in: International journal of cancer Vol. 118; no. 5; pp. 1325 - 1329
• Main Authors: Scott, Michael, McCluggage, W. Glenn, Hillan, Kenneth J., Hall, Peter A., Russell, S.E. Hilary
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.03.2006; Wiley-Liss
• Subjects: Biological and medical sciences; Cell Transformation, Neoplastic - genetics; DNA, Complementary - genetics; Female; Female genital diseases; Gene Expression Regulation, Neoplastic; GTP Phosphohydrolases - genetics; Gynecology. Andrology. Obstetrics; Humans; Medical sciences; Oligonucleotide Array Sequence Analysis; ovarian neoplasia; Ovarian Neoplasms - genetics; Ovarian Neoplasms - pathology; SEPT9; Septins; splice variants; Transcription, Genetic; Tumors; Human; Alternative splicing; Transcription; Ovary cancer; ovarian neoplasia; splice variants; Tumorigenicity; Malignant tumor; Carcinogenesis; Female genital diseases; Ovarian diseases; SEPT9; Cancerology; Gene; Genetics; Septin

Ovarian carcinoma represents the most lethal gynaecological malignancy. A variety of morphological subtypes are recognised (e.g. serous, mucinous, endometrioid), which may be benign, borderline or malignant. While their relationship is controversial, knowledge of the molecular mechanisms of ovarian...