Altered patterns of transcription of the septin gene, SEPT9, in ovarian tumorigenesis
Ovarian carcinoma represents the most lethal gynaecological malignancy. A variety of morphological subtypes are recognised (e.g. serous, mucinous, endometrioid), which may be benign, borderline or malignant. While their relationship is controversial, knowledge of the molecular mechanisms of ovarian...
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Published in | International journal of cancer Vol. 118; no. 5; pp. 1325 - 1329 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Wiley Subscription Services, Inc., A Wiley Company
01.03.2006
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Abstract | Ovarian carcinoma represents the most lethal gynaecological malignancy. A variety of morphological subtypes are recognised (e.g. serous, mucinous, endometrioid), which may be benign, borderline or malignant. While their relationship is controversial, knowledge of the molecular mechanisms of ovarian tumorigenesis may help resolve this issue and perhaps identify early markers of disease. Perturbed patterns of expression of the SEPT9 gene on chromosome 17q25.3 have been implicated in a variety of tumour types including both breast and ovarian neoplasia. In preliminary studies, we showed that SEPT9 mRNA was upregulated in a bank of ovarian tumours, which included benign, borderline and malignant tumours, and reported increased levels of one splice variant, SEPT9_v4*. We now describe a comprehensive analysis of SEPT9 expression specifically in serous and mucinous ovarian tumours (benign, borderline and malignant), using cDNA microarray, semi‐ and quantitative RTPCR of microdissected archival tumour material. Our data show consistent and specific overexpression of both SEPT9_v1 and SEPT9_v4* transcripts in the epithelial component of ovarian tumours. These transcripts show highest levels of expression in serous and mucinous borderline tumours. SEPT9_v1 is also upregulated in both serous and mucinous carcinomas. Interestingly, highest levels of expression are observed in serous borderline and low‐grade tumours rather than high‐grade in keeping with a model of progression of benign, borderline and low‐grade serous tumours. © 2005 Wiley‐Liss, Inc. |
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AbstractList | Ovarian carcinoma represents the most lethal gynaecological malignancy. A variety of morphological subtypes are recognised (e.g. serous, mucinous, endometrioid), which may be benign, borderline or malignant. While their relationship is controversial, knowledge of the molecular mechanisms of ovarian tumorigenesis may help resolve this issue and perhaps identify early markers of disease. Perturbed patterns of expression of the SEPT9 gene on chromosome 17q25.3 have been implicated in a variety of tumour types including both breast and ovarian neoplasia. In preliminary studies, we showed that SEPT9 mRNA was upregulated in a bank of ovarian tumours, which included benign, borderline and malignant tumours, and reported increased levels of one splice variant, SEPT9_v4*. We now describe a comprehensive analysis of SEPT9 expression specifically in serous and mucinous ovarian tumours (benign, borderline and malignant), using cDNA microarray, semi- and quantitative RTPCR of microdissected archival tumour material. Our data show consistent and specific overexpression of both SEPT9_v1 and SEPT9_v4* transcripts in the epithelial component of ovarian tumours. These transcripts show highest levels of expression in serous and mucinous borderline tumours. SEPT9_v1 is also upregulated in both serous and mucinous carcinomas. Interestingly, highest levels of expression are observed in serous borderline and low-grade tumours rather than high-grade in keeping with a model of progression of benign, borderline and low-grade serous tumours. Ovarian carcinoma represents the most lethal gynaecological malignancy. A variety of morphological subtypes are recognised (e.g. serous, mucinous, endometrioid), which may be benign, borderline or malignant. While their relationship is controversial, knowledge of the molecular mechanisms of ovarian tumorigenesis may help resolve this issue and perhaps identify early markers of disease. Perturbed patterns of expression of the SEPT9 gene on chromosome 17q25.3 have been implicated in a variety of tumour types including both breast and ovarian neoplasia. In preliminary studies, we showed that SEPT9 mRNA was upregulated in a bank of ovarian tumours, which included benign, borderline and malignant tumours, and reported increased levels of one splice variant, SEPT9_v4*. We now describe a comprehensive analysis of SEPT9 expression specifically in serous and mucinous ovarian tumours (benign, borderline and malignant), using cDNA microarray, semi‐ and quantitative RTPCR of microdissected archival tumour material. Our data show consistent and specific overexpression of both SEPT9_v1 and SEPT9_v4* transcripts in the epithelial component of ovarian tumours. These transcripts show highest levels of expression in serous and mucinous borderline tumours. SEPT9_v1 is also upregulated in both serous and mucinous carcinomas. Interestingly, highest levels of expression are observed in serous borderline and low‐grade tumours rather than high‐grade in keeping with a model of progression of benign, borderline and low‐grade serous tumours. © 2005 Wiley‐Liss, Inc. Ovarian carcinoma represents the most lethal gynaecological malignancy. A variety of morphological subtypes are recognised ( e.g . serous, mucinous, endometrioid), which may be benign, borderline or malignant. While their relationship is controversial, knowledge of the molecular mechanisms of ovarian tumorigenesis may help resolve this issue and perhaps identify early markers of disease. Perturbed patterns of expression of the SEPT9 gene on chromosome 17q25.3 have been implicated in a variety of tumour types including both breast and ovarian neoplasia. In preliminary studies, we showed that SEPT9 mRNA was upregulated in a bank of ovarian tumours, which included benign, borderline and malignant tumours, and reported increased levels of one splice variant, SEPT9 _v4*. We now describe a comprehensive analysis of SEPT9 expression specifically in serous and mucinous ovarian tumours (benign, borderline and malignant), using cDNA microarray, semi‐ and quantitative RTPCR of microdissected archival tumour material. Our data show consistent and specific overexpression of both SEPT9 _v1 and SEPT9 _v4* transcripts in the epithelial component of ovarian tumours. These transcripts show highest levels of expression in serous and mucinous borderline tumours. SEPT9 _v1 is also upregulated in both serous and mucinous carcinomas. Interestingly, highest levels of expression are observed in serous borderline and low‐grade tumours rather than high‐grade in keeping with a model of progression of benign, borderline and low‐grade serous tumours. © 2005 Wiley‐Liss, Inc. |
Author | Russell, S.E. Hilary Scott, Michael McCluggage, W. Glenn Hillan, Kenneth J. Hall, Peter A. |
Author_xml | – sequence: 1 givenname: Michael surname: Scott fullname: Scott, Michael – sequence: 2 givenname: W. Glenn surname: McCluggage fullname: McCluggage, W. Glenn – sequence: 3 givenname: Kenneth J. surname: Hillan fullname: Hillan, Kenneth J. – sequence: 4 givenname: Peter A. surname: Hall fullname: Hall, Peter A. – sequence: 5 givenname: S.E. Hilary surname: Russell fullname: Russell, S.E. Hilary email: seh.russell@qub.ac.uk |
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Keywords | Human Alternative splicing Transcription Ovary cancer ovarian neoplasia splice variants Tumorigenicity Malignant tumor Carcinogenesis Female genital diseases Ovarian diseases SEPT9 Cancerology Gene Genetics Septin |
Language | English |
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Snippet | Ovarian carcinoma represents the most lethal gynaecological malignancy. A variety of morphological subtypes are recognised (e.g. serous, mucinous,... Ovarian carcinoma represents the most lethal gynaecological malignancy. A variety of morphological subtypes are recognised ( e.g . serous, mucinous,... |
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SubjectTerms | Biological and medical sciences Cell Transformation, Neoplastic - genetics DNA, Complementary - genetics Female Female genital diseases Gene Expression Regulation, Neoplastic GTP Phosphohydrolases - genetics Gynecology. Andrology. Obstetrics Humans Medical sciences Oligonucleotide Array Sequence Analysis ovarian neoplasia Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology SEPT9 Septins splice variants Transcription, Genetic Tumors |
Title | Altered patterns of transcription of the septin gene, SEPT9, in ovarian tumorigenesis |
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